tetano
Editor, Senior Moderator
J Allergy Clin Immunol Pract. 2020 Apr 21. pii: S2213-2198(20)30370-6. doi: 10.1016/j.jaip.2020.04.019. [Epub ahead of print]
Preserved cellular immunity upon influenza vaccination in most patients with common variable immunodeficiency.
Friedmann D[SUP]1[/SUP], Goldacker S[SUP]2[/SUP], Peter HH[SUP]2[/SUP], Warnatz K[SUP]3[/SUP].
Author information
Abstract
BACKGROUND:
Vaccination against influenza is recommended for patients with common variable immunodeficiency (CVID), although humoral immune responses in these patients are impaired and the evidence of effective T-cell responses in CVID is not well established.
OBJECTIVE:
To determine plasmablast and T-cellular vaccination responses against influenza in patients with CVID METHODS: CVID patients and healthy controls were vaccinated with the quadrivalent vaccine Influsplit Tetra 2018/2019. Before and one week after vaccination plasmablasts and circulating ICOS expressing T follicular helper cells were measured to determine positive vaccine responses in these patients. Additionally, antigen-specific T cells were determined by their upregulation of CD25 and OX40 after in vitro re-stimulation with the vaccine.
RESULTS:
The majority of healthy controls but only one CVID patient mounted a positive humoral immune response, measured by an increase of plasmablasts one week after vaccination. In contrast, the majority of CVID patients showed an increase of ICOS+ T[SUB]FH[/SUB] cells and/or an increase of antigen-specific CD25+OX40+ T cells one week after vaccination demonstrating a positive T-cellular immune response.
CONCLUSION:
Despite the remaining challenge of accurately assessing the complexity of T-cell responses the recommendation of vaccinating CVID patients against influenza is reasonable.
Copyright ? 2020. Published by Elsevier Inc.
PMID:32330665DOI:10.1016/j.jaip.2020.04.019
Preserved cellular immunity upon influenza vaccination in most patients with common variable immunodeficiency.
Friedmann D[SUP]1[/SUP], Goldacker S[SUP]2[/SUP], Peter HH[SUP]2[/SUP], Warnatz K[SUP]3[/SUP].
Author information
Abstract
BACKGROUND:
Vaccination against influenza is recommended for patients with common variable immunodeficiency (CVID), although humoral immune responses in these patients are impaired and the evidence of effective T-cell responses in CVID is not well established.
OBJECTIVE:
To determine plasmablast and T-cellular vaccination responses against influenza in patients with CVID METHODS: CVID patients and healthy controls were vaccinated with the quadrivalent vaccine Influsplit Tetra 2018/2019. Before and one week after vaccination plasmablasts and circulating ICOS expressing T follicular helper cells were measured to determine positive vaccine responses in these patients. Additionally, antigen-specific T cells were determined by their upregulation of CD25 and OX40 after in vitro re-stimulation with the vaccine.
RESULTS:
The majority of healthy controls but only one CVID patient mounted a positive humoral immune response, measured by an increase of plasmablasts one week after vaccination. In contrast, the majority of CVID patients showed an increase of ICOS+ T[SUB]FH[/SUB] cells and/or an increase of antigen-specific CD25+OX40+ T cells one week after vaccination demonstrating a positive T-cellular immune response.
CONCLUSION:
Despite the remaining challenge of accurately assessing the complexity of T-cell responses the recommendation of vaccinating CVID patients against influenza is reasonable.
Copyright ? 2020. Published by Elsevier Inc.
PMID:32330665DOI:10.1016/j.jaip.2020.04.019