sharon sanders
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Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
View ORCID ProfileDavid Brann, View ORCID ProfileTatsuya Tsukahara, View ORCID ProfileCaleb Weinreb, Marcela Lipovsek, View ORCID ProfileKoen Van den Berge, Boying Gong, Rebecca Chance, Iain C Macaulay, Hsin-jung Chou, Russell Fletcher, View ORCID ProfileDiya Das, View ORCID ProfileKelly Street, View ORCID ProfileHector Roux de Bezieux, Yoon-Gi Choi, Davide Risso, Sandrine Dudoit, View ORCID ProfileElizabeth Purdom, Jonathan C Mill, Ralph Abi Hachem, Hiroaki Matsunami, Darren W. Logan, Bradley Goldstein, Matthew S Grubb, John Ngai, View ORCID ProfileSandeep Robert Datta
doi: https://doi.org/10.1101/2020.03.25.009084
This article is a preprint and has not been certified by peer review [what does this mean?].
Abstract
A subset of COVID-19 patients exhibit altered olfactory function. Here we analyze bulk and single cell RNA-Seq datasets to identify cell types in the olfactory epithelium and olfactory bulb that express cell entry molecules that mediate infection by SARS-CoV-2 (CoV-2), the causal agent in COVID-19. We find that samples from whole olfactory mucosa in species including mouse and human express two key genes involved in CoV-2 entry, ACE2 and TMPRSS2. However, neither olfactory sensory neurons nor olfactory bulb neurons express these genes, which are instead expressed in support cells, stem cells, and perivascular cells. These findings suggest that CoV-2 infection of non-neuronal cell types leads to anosmia and related disturbances in odor perception in COVID-19 patients.
https://www.biorxiv.org/content/10.1...03.25.009084v3
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
View ORCID ProfileDavid Brann, View ORCID ProfileTatsuya Tsukahara, View ORCID ProfileCaleb Weinreb, Marcela Lipovsek, View ORCID ProfileKoen Van den Berge, Boying Gong, Rebecca Chance, Iain C Macaulay, Hsin-jung Chou, Russell Fletcher, View ORCID ProfileDiya Das, View ORCID ProfileKelly Street, View ORCID ProfileHector Roux de Bezieux, Yoon-Gi Choi, Davide Risso, Sandrine Dudoit, View ORCID ProfileElizabeth Purdom, Jonathan C Mill, Ralph Abi Hachem, Hiroaki Matsunami, Darren W. Logan, Bradley Goldstein, Matthew S Grubb, John Ngai, View ORCID ProfileSandeep Robert Datta
doi: https://doi.org/10.1101/2020.03.25.009084
This article is a preprint and has not been certified by peer review [what does this mean?].
Abstract
A subset of COVID-19 patients exhibit altered olfactory function. Here we analyze bulk and single cell RNA-Seq datasets to identify cell types in the olfactory epithelium and olfactory bulb that express cell entry molecules that mediate infection by SARS-CoV-2 (CoV-2), the causal agent in COVID-19. We find that samples from whole olfactory mucosa in species including mouse and human express two key genes involved in CoV-2 entry, ACE2 and TMPRSS2. However, neither olfactory sensory neurons nor olfactory bulb neurons express these genes, which are instead expressed in support cells, stem cells, and perivascular cells. These findings suggest that CoV-2 infection of non-neuronal cell types leads to anosmia and related disturbances in odor perception in COVID-19 patients.
https://www.biorxiv.org/content/10.1...03.25.009084v3
