Commonground
Senior Moderator
Posted July 4, 2024
Yuxin Guo, Sicheng Shu, Yong Zhou, Wenjing Peng, Zhimin Jiang, Yudong Li, Tian Li, Fanshu Du, Linlin Wang, Xue Chen, Jinze Dong, Chuankuo Zhao, Maggie Haitian Wang, Yipeng Sun, Honglei Sun, Lu Lu, Paul Digard, Kin-chow Chang, Hui-Ling Yen, Jinhua Liu, Juan Pu
doi: https://doi.org/10.1101/2024.07.03.601996
This article is a preprint and has not been certified by peer review [what does this mean?].
Abstract:
Alterations in the PB2-627 domain could substantially increase the risk of an avian influenza virus (AIV) pandemic. Here, we discovered a variant, PB2-627V, which combines the properties of avian-like PB2-627E and human-like PB2-627K. This variant not only maintains viral fitness in chickens but also facilitates the aerosol transmission of AIVs between ferrets. Mechanistically, PB2-627V utilizes both avian and human host protein ANP32A to support viral polymerase function. Therefore, this mutation overcomes the barrier between birds and humans, greatly enhancing the likelihood of AIVs infecting humans. The PB2-627V polymorphism has been found in birds, humans, and mammals worldwide across more than ten AIV subtypes. Given the escalating global spread of AIVs, it is crucial to closely monitor influenza viruses carrying PB2-627V to prevent a pandemic. Competing Interest Statement
The authors have declared no competing interest.
https://www.biorxiv.org/content/10.1101/2024.07.03.601996v1
Yuxin Guo, Sicheng Shu, Yong Zhou, Wenjing Peng, Zhimin Jiang, Yudong Li, Tian Li, Fanshu Du, Linlin Wang, Xue Chen, Jinze Dong, Chuankuo Zhao, Maggie Haitian Wang, Yipeng Sun, Honglei Sun, Lu Lu, Paul Digard, Kin-chow Chang, Hui-Ling Yen, Jinhua Liu, Juan Pu
doi: https://doi.org/10.1101/2024.07.03.601996
This article is a preprint and has not been certified by peer review [what does this mean?].
Abstract:
Alterations in the PB2-627 domain could substantially increase the risk of an avian influenza virus (AIV) pandemic. Here, we discovered a variant, PB2-627V, which combines the properties of avian-like PB2-627E and human-like PB2-627K. This variant not only maintains viral fitness in chickens but also facilitates the aerosol transmission of AIVs between ferrets. Mechanistically, PB2-627V utilizes both avian and human host protein ANP32A to support viral polymerase function. Therefore, this mutation overcomes the barrier between birds and humans, greatly enhancing the likelihood of AIVs infecting humans. The PB2-627V polymorphism has been found in birds, humans, and mammals worldwide across more than ten AIV subtypes. Given the escalating global spread of AIVs, it is crucial to closely monitor influenza viruses carrying PB2-627V to prevent a pandemic. Competing Interest Statement
The authors have declared no competing interest.
https://www.biorxiv.org/content/10.1101/2024.07.03.601996v1