tetano
Editor, Senior Moderator
Prenat Diagn
. 2021 Jun 8.
doi: 10.1002/pd.5980. Online ahead of print.
Vertical transmission of SARS-CoV2 during pregnancy: A high-risk cohort
Mariane de Fátima Yukie Maeda[SUP] 1 [/SUP], Maria de Lourdes Brizot[SUP] 1 [/SUP], Maria Augusta B C Gibelli[SUP] 2 [/SUP], Silvia Maria Ibidi[SUP] 2 3 [/SUP], Werther Brunow de Carvalho[SUP] 2 3 [/SUP], Mara Sandra Hoshida[SUP] 1 [/SUP], Clarisse Martins Machado[SUP] 4 [/SUP], Ester Cerdeira Sabino[SUP] 5 [/SUP], Lea Campos de Oliveira da Silva[SUP] 6 [/SUP], Thomas Jaenisch[SUP] 7 8 [/SUP], Maria Cassia Mendes-Correa[SUP] 4 [/SUP], Philippe Mayaud[SUP] 9 [/SUP], Rossana Pulcineli Vieira Francisco[SUP] 1 3 [/SUP], HC-FMUSP-Obstetric COVID19 Study Group
Affiliations
Abstract
Objective: Identify the potential for and risk factors of SARS-CoV-2 vertical transmission.
Methods: Symptomatic pregnant women with COVID-19 diagnosis in whom PCR for SARS-CoV-2 was performed at delivery using maternal serum and at least one of the biological samples: cord blood (CB), amniotic fluid (AF), colostrum and/or oropharyngeal swab (OPS) of the neonate. The association of parameters with maternal, AF and/or CB positivity and the influence of SARS-CoV-2 positivity in AF and/or CB on neonatal outcomes were investigated.
Results: Overall 73.4% (80/109) were admitted in hospital due to COVID-19, 22.9% needed intensive care and there were four maternal deaths. Positive RT-PCR for SARS-CoV-2 was observed in 14.7% of maternal blood, 13.9% of AF, 6.7% of CB, 2.1% of colostrum and 3.7% of OPS samples. The interval between COVID-19 symptoms and delivery was inversely associated with SARS-CoV-2 positivity in the maternal blood (P=0.002) and in the AF and/or CB (P=0.049). Maternal viremia was associated with positivity for SARS-CoV-2 in AF and/or CB (P= 0.001). SARS-CoV-2 positivity in the compartments was not associated with neonatal outcomes.
Conclusion: Vertical transmission is possible in pregnant women with COVID-19 and a shorter interval between maternal symptoms and delivery is an influencing factor. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-CoV-2; coronavirus disease 2019; fetal development; fetal diseases; pregnancy complcations; vertical/mother-to-child transmission.
. 2021 Jun 8.
doi: 10.1002/pd.5980. Online ahead of print.
Vertical transmission of SARS-CoV2 during pregnancy: A high-risk cohort
Mariane de Fátima Yukie Maeda[SUP] 1 [/SUP], Maria de Lourdes Brizot[SUP] 1 [/SUP], Maria Augusta B C Gibelli[SUP] 2 [/SUP], Silvia Maria Ibidi[SUP] 2 3 [/SUP], Werther Brunow de Carvalho[SUP] 2 3 [/SUP], Mara Sandra Hoshida[SUP] 1 [/SUP], Clarisse Martins Machado[SUP] 4 [/SUP], Ester Cerdeira Sabino[SUP] 5 [/SUP], Lea Campos de Oliveira da Silva[SUP] 6 [/SUP], Thomas Jaenisch[SUP] 7 8 [/SUP], Maria Cassia Mendes-Correa[SUP] 4 [/SUP], Philippe Mayaud[SUP] 9 [/SUP], Rossana Pulcineli Vieira Francisco[SUP] 1 3 [/SUP], HC-FMUSP-Obstetric COVID19 Study Group
Affiliations
- PMID: 34101871
- DOI: 10.1002/pd.5980
Abstract
Objective: Identify the potential for and risk factors of SARS-CoV-2 vertical transmission.
Methods: Symptomatic pregnant women with COVID-19 diagnosis in whom PCR for SARS-CoV-2 was performed at delivery using maternal serum and at least one of the biological samples: cord blood (CB), amniotic fluid (AF), colostrum and/or oropharyngeal swab (OPS) of the neonate. The association of parameters with maternal, AF and/or CB positivity and the influence of SARS-CoV-2 positivity in AF and/or CB on neonatal outcomes were investigated.
Results: Overall 73.4% (80/109) were admitted in hospital due to COVID-19, 22.9% needed intensive care and there were four maternal deaths. Positive RT-PCR for SARS-CoV-2 was observed in 14.7% of maternal blood, 13.9% of AF, 6.7% of CB, 2.1% of colostrum and 3.7% of OPS samples. The interval between COVID-19 symptoms and delivery was inversely associated with SARS-CoV-2 positivity in the maternal blood (P=0.002) and in the AF and/or CB (P=0.049). Maternal viremia was associated with positivity for SARS-CoV-2 in AF and/or CB (P= 0.001). SARS-CoV-2 positivity in the compartments was not associated with neonatal outcomes.
Conclusion: Vertical transmission is possible in pregnant women with COVID-19 and a shorter interval between maternal symptoms and delivery is an influencing factor. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-CoV-2; coronavirus disease 2019; fetal development; fetal diseases; pregnancy complcations; vertical/mother-to-child transmission.