tetano
Editor, Senior Moderator
Vaccine. 2013 Sep 5. pii: S0264-410X(13)01170-5. doi: 10.1016/j.vaccine.2013.08.058. [Epub ahead of print]
Preliminary data on immunogenicity, safety and tolerability of trivalent inactivated influenza vaccine in children with inborn errors of metabolism at risk of decompensation.
Esposito S, Salvini F, Menni F, Scala A, Salvatici E, Manzoni F, Riva E, Giovannini M, Principi N.
Source
Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universit? degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: susanna.esposito@unimi.it.
Abstract
In order to evaluate the immunogenicity, safety and tolerability of influenza vaccination in children with inborn errors of metabolism (IEMs), we enrolled 20 patients with IEMs at risk of decompensation (14 males; mean age?SD, 8.5?3.9years) and 20 healthy age- and gender-matched controls. Four weeks after vaccination, seroconversion rates were 75-85% and seroprotection rates 85-95%, with high geometric mean titers (GMTs) of all three influenza antigen strains in both groups. Three months after vaccination, most of the subjects remained seroconverted with high seroprotection rates and high GMTs for all the three influenza strains. Safety and tolerability were also very good, with no differences between the groups.
Copyright ? 2013. Published by Elsevier Ltd.
KEYWORDS:
Children, Influenza vaccine, Influenza virus, Metabolic disease, Trivalent influenza vaccine
PMID:
24012567
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24012567
Preliminary data on immunogenicity, safety and tolerability of trivalent inactivated influenza vaccine in children with inborn errors of metabolism at risk of decompensation.
Esposito S, Salvini F, Menni F, Scala A, Salvatici E, Manzoni F, Riva E, Giovannini M, Principi N.
Source
Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universit? degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: susanna.esposito@unimi.it.
Abstract
In order to evaluate the immunogenicity, safety and tolerability of influenza vaccination in children with inborn errors of metabolism (IEMs), we enrolled 20 patients with IEMs at risk of decompensation (14 males; mean age?SD, 8.5?3.9years) and 20 healthy age- and gender-matched controls. Four weeks after vaccination, seroconversion rates were 75-85% and seroprotection rates 85-95%, with high geometric mean titers (GMTs) of all three influenza antigen strains in both groups. Three months after vaccination, most of the subjects remained seroconverted with high seroprotection rates and high GMTs for all the three influenza strains. Safety and tolerability were also very good, with no differences between the groups.
Copyright ? 2013. Published by Elsevier Ltd.
KEYWORDS:
Children, Influenza vaccine, Influenza virus, Metabolic disease, Trivalent influenza vaccine
PMID:
24012567
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24012567