tetano
Editor, Senior Moderator
Clin Immunol. 2019 Aug 27:108254. doi: 10.1016/j.clim.2019.108254. [Epub ahead of print]
[h=1]Pregnancy-related immune suppression leads to altered influenza vaccine recall responses.[/h] Shah NM[SUP]1[/SUP], Imami N[SUP]2[/SUP], Kelleher P[SUP]2[/SUP], Barclay WS[SUP]2[/SUP], Johnson MR[SUP]3[/SUP].
[h=3]Author information[/h] 1 Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom. Electronic address: nishel.shah@imperial.ac.uk. 2 Department of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom. 3 Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom.
[h=3]Abstract[/h] Pregnancy is a risk factor for severe influenza infection. Despite achieving seroprotective antibody titres post immunisation fewer pregnant women experience a reduction in influenza-like illness compared to non-pregnant cohorts. This may be due to the effects that immune-modulation in pregnancy has on vaccine efficacy leading to a less favourable immunologic response. To understand this, we investigated the antigen-specific cellular responses and leukocyte phenotype in pregnant and non-pregnant women who achieved seroprotection post immunisation. We show that although pregnancy is associated with better antigen-specific inflammatory (IFN-γ) responses and an expansion of central memory T cells (Tcm) post immunisation, but low-level pregnancy-related immune regulation (HLA-G, PIBF) and associated reduced B-cell antibody maintenance (TGF-β) suggest poor immunologic responses compared to the non-pregnant. Thus far, studies of influenza vaccine immunogenicity have focused on the induction of antibodies but understanding additional vaccine-related cellular responses is needed to fully appreciate how pregnancy impacts on vaccine effectiveness.
Copyright ? 2018. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] Influenza; Pregnancy; Tolerance; Vaccination
PMID: 31470087 DOI: 10.1016/j.clim.2019.108254
[h=1]Pregnancy-related immune suppression leads to altered influenza vaccine recall responses.[/h] Shah NM[SUP]1[/SUP], Imami N[SUP]2[/SUP], Kelleher P[SUP]2[/SUP], Barclay WS[SUP]2[/SUP], Johnson MR[SUP]3[/SUP].
[h=3]Author information[/h] 1 Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom. Electronic address: nishel.shah@imperial.ac.uk. 2 Department of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom. 3 Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom.
[h=3]Abstract[/h] Pregnancy is a risk factor for severe influenza infection. Despite achieving seroprotective antibody titres post immunisation fewer pregnant women experience a reduction in influenza-like illness compared to non-pregnant cohorts. This may be due to the effects that immune-modulation in pregnancy has on vaccine efficacy leading to a less favourable immunologic response. To understand this, we investigated the antigen-specific cellular responses and leukocyte phenotype in pregnant and non-pregnant women who achieved seroprotection post immunisation. We show that although pregnancy is associated with better antigen-specific inflammatory (IFN-γ) responses and an expansion of central memory T cells (Tcm) post immunisation, but low-level pregnancy-related immune regulation (HLA-G, PIBF) and associated reduced B-cell antibody maintenance (TGF-β) suggest poor immunologic responses compared to the non-pregnant. Thus far, studies of influenza vaccine immunogenicity have focused on the induction of antibodies but understanding additional vaccine-related cellular responses is needed to fully appreciate how pregnancy impacts on vaccine effectiveness.
Copyright ? 2018. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] Influenza; Pregnancy; Tolerance; Vaccination
PMID: 31470087 DOI: 10.1016/j.clim.2019.108254