tetano
Editor, Senior Moderator
Sci Immunol. 2017 Jul 14;2(13). pii: eaan2676. doi: 10.1126/sciimmunol.aan2676.
[h=1]Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.[/h] Andrews SF[SUP]1[/SUP], Joyce MG[SUP]2[/SUP], Chambers MJ[SUP]2[/SUP], Gillespie RA[SUP]2[/SUP], Kanekiyo M[SUP]2[/SUP], Leung K[SUP]2[/SUP], Yang ES[SUP]2[/SUP], Tsybovsky Y[SUP]3[/SUP], Wheatley AK[SUP]4[/SUP], Crank MC[SUP]2[/SUP], Boyington JC[SUP]2[/SUP], Prabhakaran MS[SUP]2[/SUP], Narpala SR[SUP]2[/SUP], Chen X[SUP]2[/SUP], Bailer RT[SUP]2[/SUP], Chen G[SUP]2[/SUP], Coates E[SUP]2[/SUP], Kwong PD[SUP]2[/SUP], Koup RA[SUP]2[/SUP], Mascola JR[SUP]2[/SUP], Graham BS[SUP]2[/SUP], Ledgerwood JE[SUP]2[/SUP], McDermott AB[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Antigenic drift and shift of influenza strains underscore the need for broadly protective influenza vaccines. One strategy is to design immunogens that elicit B cell responses against conserved epitopes on the hemagglutinin (HA) stem. To better understand the elicitation of HA stem-targeted B cells to group 1 and group 2 influenza subtypes, we compared the memory B cell response to group 2 H7N9 and group 1 H5N1 vaccines in humans. Upon H7N9 vaccination, almost half of the HA stem-specific response recognized the group 1 and group 2 subtypes, whereas the response to H5N1 was largely group 1-specific. Immunoglobulin repertoire analysis of HA-specific B cells indicated that the H7N9 and H5N1 vaccines induced genetically similar cross-group HA stem-binding B cells, albeit at a much higher frequency upon H7N9 vaccination. These data suggest that a group 2-based stem immunogen could prove more effective than a group 1 immunogen at eliciting broad cross-group protection in humans.
Copyright ? 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PMID: 28783708 DOI: 10.1126/sciimmunol.aan2676
[h=1]Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.[/h] Andrews SF[SUP]1[/SUP], Joyce MG[SUP]2[/SUP], Chambers MJ[SUP]2[/SUP], Gillespie RA[SUP]2[/SUP], Kanekiyo M[SUP]2[/SUP], Leung K[SUP]2[/SUP], Yang ES[SUP]2[/SUP], Tsybovsky Y[SUP]3[/SUP], Wheatley AK[SUP]4[/SUP], Crank MC[SUP]2[/SUP], Boyington JC[SUP]2[/SUP], Prabhakaran MS[SUP]2[/SUP], Narpala SR[SUP]2[/SUP], Chen X[SUP]2[/SUP], Bailer RT[SUP]2[/SUP], Chen G[SUP]2[/SUP], Coates E[SUP]2[/SUP], Kwong PD[SUP]2[/SUP], Koup RA[SUP]2[/SUP], Mascola JR[SUP]2[/SUP], Graham BS[SUP]2[/SUP], Ledgerwood JE[SUP]2[/SUP], McDermott AB[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Antigenic drift and shift of influenza strains underscore the need for broadly protective influenza vaccines. One strategy is to design immunogens that elicit B cell responses against conserved epitopes on the hemagglutinin (HA) stem. To better understand the elicitation of HA stem-targeted B cells to group 1 and group 2 influenza subtypes, we compared the memory B cell response to group 2 H7N9 and group 1 H5N1 vaccines in humans. Upon H7N9 vaccination, almost half of the HA stem-specific response recognized the group 1 and group 2 subtypes, whereas the response to H5N1 was largely group 1-specific. Immunoglobulin repertoire analysis of HA-specific B cells indicated that the H7N9 and H5N1 vaccines induced genetically similar cross-group HA stem-binding B cells, albeit at a much higher frequency upon H7N9 vaccination. These data suggest that a group 2-based stem immunogen could prove more effective than a group 1 immunogen at eliciting broad cross-group protection in humans.
Copyright ? 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PMID: 28783708 DOI: 10.1126/sciimmunol.aan2676