tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2013 Aug 4. doi: 10.1111/1469-0691.12352. [Epub ahead of print]
Predictors of H1N1 influenza in the emergency department: proposition for a modified H1N1 case definition.
Flick H, Drescher M, Prattes J, Tovilo K, H Kessler H, Vander K, Seeber K, Palfner M, Raggam RB, Avian A, Krause R, Hoenigl M.
Source
Division of Pulmonology, Medical University of Graz, Graz, Austria.
Abstract
Reliable and rapid diagnosis of influenza A H1N1 is essential to initiate appropriate antiviral therapy and preventive measures. We analysed the differences in clinical presentation and laboratory parameters between emergency department patients with PCR-confirmed H1N1 influenza infection (n = 199) and those with PCR-negative influenza-like illness (ILI; n = 252). Cough, wheezing, leucopenia, eosinopenia and a lower C-reactive protein remained significant predictors of H1N1 influenza. Proposed combinations of clinical symptoms with simple laboratory parameters (e.g. reported or measured fever and either cough or leucocytes <8.5 ? 109 /L) were clearly superior to currently used official ILI case definitions that use clinical criteria alone.
? 2013 The Authors Clinical Microbiology and Infection ? 2013 European Society of Clinical Microbiology and Infectious Diseases.
KEYWORDS:
PCR , Berlin, H1N1, clinical presentation, influenza A, laboratory values
PMID:
24004327
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24004327
Predictors of H1N1 influenza in the emergency department: proposition for a modified H1N1 case definition.
Flick H, Drescher M, Prattes J, Tovilo K, H Kessler H, Vander K, Seeber K, Palfner M, Raggam RB, Avian A, Krause R, Hoenigl M.
Source
Division of Pulmonology, Medical University of Graz, Graz, Austria.
Abstract
Reliable and rapid diagnosis of influenza A H1N1 is essential to initiate appropriate antiviral therapy and preventive measures. We analysed the differences in clinical presentation and laboratory parameters between emergency department patients with PCR-confirmed H1N1 influenza infection (n = 199) and those with PCR-negative influenza-like illness (ILI; n = 252). Cough, wheezing, leucopenia, eosinopenia and a lower C-reactive protein remained significant predictors of H1N1 influenza. Proposed combinations of clinical symptoms with simple laboratory parameters (e.g. reported or measured fever and either cough or leucocytes <8.5 ? 109 /L) were clearly superior to currently used official ILI case definitions that use clinical criteria alone.
? 2013 The Authors Clinical Microbiology and Infection ? 2013 European Society of Clinical Microbiology and Infectious Diseases.
KEYWORDS:
PCR , Berlin, H1N1, clinical presentation, influenza A, laboratory values
PMID:
24004327
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24004327