tetano
Editor, Senior Moderator
J Infect Dis. 2014 Jun 27. pii: jiu366. [Epub ahead of print]
Pre- and post-pandemic estimates of influenza A(H1N1)pdm09 sero-protection to inform surveillance-based incidence by age during the 2013-14 epidemic in Canada.
Skowronski DM1, Chambers C2, Sabaiduc S1, Janjua NZ1, Li G2, Petric M1, Krajden M1, Purych D3, Li Y4, De Serres G5.
Author information
Abstract
To understand A(H1N1)pdm09 epidemic resurgence during the 2013-14 influenza season, we compared age-related cross-sectional estimates of sero-protection pre-pandemic (2009) and post-pandemic (2010 and 2013) to subsequent surveillance-based laboratory-confirmed A(H1N1)pdm09 incidence in British Columbia, Canada. Pre-pandemic sero-protection was negligible except among the very old ?80 years (80%). Conversely, post-pandemic sero-protection followed a U-shaped distribution: ∼35-45% among working-age adults but ?70% in the very old and young children, excluding children <5years in 2013 for whom sero-protection again fell below 20%. Incidence was 5-fold higher in 2013-14 than 2010-11, highest in preschool-aged children and working-age adults, following a mirror-image of sero-protection by age.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
24973459
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24973459
Pre- and post-pandemic estimates of influenza A(H1N1)pdm09 sero-protection to inform surveillance-based incidence by age during the 2013-14 epidemic in Canada.
Skowronski DM1, Chambers C2, Sabaiduc S1, Janjua NZ1, Li G2, Petric M1, Krajden M1, Purych D3, Li Y4, De Serres G5.
Author information
Abstract
To understand A(H1N1)pdm09 epidemic resurgence during the 2013-14 influenza season, we compared age-related cross-sectional estimates of sero-protection pre-pandemic (2009) and post-pandemic (2010 and 2013) to subsequent surveillance-based laboratory-confirmed A(H1N1)pdm09 incidence in British Columbia, Canada. Pre-pandemic sero-protection was negligible except among the very old ?80 years (80%). Conversely, post-pandemic sero-protection followed a U-shaped distribution: ∼35-45% among working-age adults but ?70% in the very old and young children, excluding children <5years in 2013 for whom sero-protection again fell below 20%. Incidence was 5-fold higher in 2013-14 than 2010-11, highest in preschool-aged children and working-age adults, following a mirror-image of sero-protection by age.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
24973459
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24973459