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The Lancet Infectious Diseases
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doi:10.1016/S1473-3099(11)70142-6 | How to Cite or Link Using DOI
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Potential role of human challenge studies for investigation of influenza transmission
Dr Ben Killingley MDa, Corresponding Author Contact Information, E-mail The Corresponding Author, Joanne Enstone MPhila, Prof Robert Booy MDb, Andrew Hayward MDc, Prof John Oxford DScd, Prof Neil Ferguson PhDe, Prof Jonathan Nguyen Van-Tam DMa and on behalf of the influenza transmission strategy development group?
a Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
b National Centre for Immunisation Research and Surveillance, and Sydney Institute of Emerging Infectious Diseases and Biosecurity, Sydney, NSW, Australia
c Centre for Infectious Disease Epidemiology, University College London, London, UK
d Centre for Infectious Diseases, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London, UK
e MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK
Available online 26 July 2011.
Summary
The importance of different routes of influenza transmission (including the role of bioaerosols) and the ability of masks and hand hygiene to prevent transmission remain poorly understood. Interest in transmission of influenza has grown as the effectiveness of prevention measures implemented during the 2009 H1N1 pandemic are questioned and as plans to better prepare for the next pandemic are debated. Recent studies of naturally infected patients have encountered difficulties and have fallen short of providing definitive answers. Human challenge studies with influenza virus date back to the 1918 pandemic. In more recent decades they have been undertaken to investigate the efficacy of antiviral agents and vaccines. Could experimental challenge studies, in which volunteers are deliberately infected with influenza virus, provide an alternative approach to the study of transmission? Here, we review the latest intervention studies and discuss the potential of challenge studies to address the remaining gaps in our knowledge.
http://www.sciencedirect.com/science/article/pii/S1473309911701426
Article in Press, Corrected Proof - Note to users
doi:10.1016/S1473-3099(11)70142-6 | How to Cite or Link Using DOI
Permissions & Reprints
Personal View
Potential role of human challenge studies for investigation of influenza transmission
Dr Ben Killingley MDa, Corresponding Author Contact Information, E-mail The Corresponding Author, Joanne Enstone MPhila, Prof Robert Booy MDb, Andrew Hayward MDc, Prof John Oxford DScd, Prof Neil Ferguson PhDe, Prof Jonathan Nguyen Van-Tam DMa and on behalf of the influenza transmission strategy development group?
a Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
b National Centre for Immunisation Research and Surveillance, and Sydney Institute of Emerging Infectious Diseases and Biosecurity, Sydney, NSW, Australia
c Centre for Infectious Disease Epidemiology, University College London, London, UK
d Centre for Infectious Diseases, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London, UK
e MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK
Available online 26 July 2011.
Summary
The importance of different routes of influenza transmission (including the role of bioaerosols) and the ability of masks and hand hygiene to prevent transmission remain poorly understood. Interest in transmission of influenza has grown as the effectiveness of prevention measures implemented during the 2009 H1N1 pandemic are questioned and as plans to better prepare for the next pandemic are debated. Recent studies of naturally infected patients have encountered difficulties and have fallen short of providing definitive answers. Human challenge studies with influenza virus date back to the 1918 pandemic. In more recent decades they have been undertaken to investigate the efficacy of antiviral agents and vaccines. Could experimental challenge studies, in which volunteers are deliberately infected with influenza virus, provide an alternative approach to the study of transmission? Here, we review the latest intervention studies and discuss the potential of challenge studies to address the remaining gaps in our knowledge.
http://www.sciencedirect.com/science/article/pii/S1473309911701426