tetano
Editor, Senior Moderator
Postgrad Med J
. 2022 Sep 2;pmj-2022-141738.
doi: 10.1136/postmj/pmj-2022-141738. Online ahead of print.
Inpatient cardiovascular outcomes in patients with cancer affected by viral influenza infection
Aakash R Sheth[SUP] 1 [/SUP], Udhayvir Singh Grewal[SUP] 2 [/SUP], Harsh P Patel[SUP] 3 [/SUP], Sahith Reddy Thotamgari[SUP] 1 [/SUP], Smit Patel[SUP] 4 [/SUP], Rohan Desai[SUP] 5 [/SUP], Samarthkumar Thakkar[SUP] 6 [/SUP], Aristotelis Papayannis[SUP] 7 [/SUP]
Affiliations
Abstract
Background: Influenza disproportionately affects individuals with underlying comorbidities. Long-term follow-up studies have shown that patients with cancer with influenza have higher mortality. However, very little is known about the in-hospital mortality and cardiovascular outcomes of influenza infection in cancer hospitalisations.
Methods: We compared the in-hospital mortality and cardiovascular outcomes in patients with cancer with and without influenza by screening the National Inpatient Sample from 2015 to 2017. A total of 9 443 421 hospitalisations with any cancer were identified, out of which 14 634 had influenza while 9 252 007 did not. A two-level hierarchical multivariate logistic regression analysis adjusted for age, sex, race, hospital type and relevant comorbidities was performed.
Results: The group with cancer and influenza had higher in-hospital mortality (OR 1.08; 95% CI 1.003 to 1.16; p=0.04), acute coronary syndromes (OR 1.74; 95% CI 1.57 to 1.93; p<0.0001), atrial fibrillation (OR 1.24; 95% CI 1.18 to 1.29; p<0.0001) and acute heart failure (OR 1.41; 95% CI 1.32 to 1.51; p<0.0001).
Conclusion: Patients with cancer affected by influenza have higher in-hospital mortality and a higher prevalence of acute coronary syndrome, atrial fibrillation and acute heart failure.
Keywords: adult cardiology; adult oncology; cardiology; myocardial infarction; public health.
. 2022 Sep 2;pmj-2022-141738.
doi: 10.1136/postmj/pmj-2022-141738. Online ahead of print.
Inpatient cardiovascular outcomes in patients with cancer affected by viral influenza infection
Aakash R Sheth[SUP] 1 [/SUP], Udhayvir Singh Grewal[SUP] 2 [/SUP], Harsh P Patel[SUP] 3 [/SUP], Sahith Reddy Thotamgari[SUP] 1 [/SUP], Smit Patel[SUP] 4 [/SUP], Rohan Desai[SUP] 5 [/SUP], Samarthkumar Thakkar[SUP] 6 [/SUP], Aristotelis Papayannis[SUP] 7 [/SUP]
Affiliations
- PMID: 37095594
- DOI: 10.1136/postmj/pmj-2022-141738
Abstract
Background: Influenza disproportionately affects individuals with underlying comorbidities. Long-term follow-up studies have shown that patients with cancer with influenza have higher mortality. However, very little is known about the in-hospital mortality and cardiovascular outcomes of influenza infection in cancer hospitalisations.
Methods: We compared the in-hospital mortality and cardiovascular outcomes in patients with cancer with and without influenza by screening the National Inpatient Sample from 2015 to 2017. A total of 9 443 421 hospitalisations with any cancer were identified, out of which 14 634 had influenza while 9 252 007 did not. A two-level hierarchical multivariate logistic regression analysis adjusted for age, sex, race, hospital type and relevant comorbidities was performed.
Results: The group with cancer and influenza had higher in-hospital mortality (OR 1.08; 95% CI 1.003 to 1.16; p=0.04), acute coronary syndromes (OR 1.74; 95% CI 1.57 to 1.93; p<0.0001), atrial fibrillation (OR 1.24; 95% CI 1.18 to 1.29; p<0.0001) and acute heart failure (OR 1.41; 95% CI 1.32 to 1.51; p<0.0001).
Conclusion: Patients with cancer affected by influenza have higher in-hospital mortality and a higher prevalence of acute coronary syndrome, atrial fibrillation and acute heart failure.
Keywords: adult cardiology; adult oncology; cardiology; myocardial infarction; public health.