tetano
Editor, Senior Moderator
Infect Drug Resist. 2017 Feb 21;10:61-67. doi: 10.2147/IDR.S122390. eCollection 2017.
[h=1]Post-influenza aspergillosis, do not underestimate influenza B.[/h] Nulens EF[SUP]1[/SUP], Bourgeois MJ[SUP]2[/SUP], Reynders MB[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Our objective is to highlight and focus on post-influenza aspergillosis, triggered by influenza B virus. This relatively new clinical entity is often associated with a fulminant course of respiratory decline and high mortality. A 51-year immunocompetent woman, without any medical history or risk factors for developing a complicated influenza infection, was admitted to the intensive care unit. During admission, she presented with an afebrile flu-like syndrome, myocarditis, rhabdomyolysis, multiple organ failure, and evolved to severe respiratory distress. The broncho-alveolar lavage contained influenza B RNA, and the culture revealed Aspergillus fumigatus. Despite maximal organ support, immunoglobulin, antiviral and antifungal therapy, the patient died. This case demonstrates that influenza B virus may be life threatening even to immunocompetent adults and may trigger an invasive Aspergillus superinfection.
[h=4]KEYWORDS:[/h] ARDS; antiviral therapy; influenza B; invasive pulmonary aspergillosis; post-influenza aspergillosis; rhabdomyolysis
PMID: 28260935 DOI: 10.2147/IDR.S122390
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[h=1]Post-influenza aspergillosis, do not underestimate influenza B.[/h] Nulens EF[SUP]1[/SUP], Bourgeois MJ[SUP]2[/SUP], Reynders MB[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Our objective is to highlight and focus on post-influenza aspergillosis, triggered by influenza B virus. This relatively new clinical entity is often associated with a fulminant course of respiratory decline and high mortality. A 51-year immunocompetent woman, without any medical history or risk factors for developing a complicated influenza infection, was admitted to the intensive care unit. During admission, she presented with an afebrile flu-like syndrome, myocarditis, rhabdomyolysis, multiple organ failure, and evolved to severe respiratory distress. The broncho-alveolar lavage contained influenza B RNA, and the culture revealed Aspergillus fumigatus. Despite maximal organ support, immunoglobulin, antiviral and antifungal therapy, the patient died. This case demonstrates that influenza B virus may be life threatening even to immunocompetent adults and may trigger an invasive Aspergillus superinfection.
[h=4]KEYWORDS:[/h] ARDS; antiviral therapy; influenza B; invasive pulmonary aspergillosis; post-influenza aspergillosis; rhabdomyolysis
PMID: 28260935 DOI: 10.2147/IDR.S122390
[PubMed - in process] Free full text