Mary Wilson
Well-known member
10 October 2023
https://doi.org/10.3389/fimmu.2023.1252367
Christian A. Devaux[SUP]1,2*[/SUP], Jacques Fantini[SUP]3[/SUP]
Since the start of the SARS-CoV-2 pandemic, the rapid replacement of one lineage by another has been observed. Indeed, SARS-CoV-2 is evolving through a quasispecies mechanism leading to post-infection mutation selection under positive evolutionary pressure (host-driven viral evolution). These mutations may reduce the effectiveness of the specific neutralizing immune response against the virus. We provide here evidence that apart from the selection of SARS-CoV-2 variants by the immune system, selection by the cellular receptor can just as well select variants which escape neutralization.
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252367/full
https://doi.org/10.3389/fimmu.2023.1252367
Christian A. Devaux[SUP]1,2*[/SUP], Jacques Fantini[SUP]3[/SUP]
Since the start of the SARS-CoV-2 pandemic, the rapid replacement of one lineage by another has been observed. Indeed, SARS-CoV-2 is evolving through a quasispecies mechanism leading to post-infection mutation selection under positive evolutionary pressure (host-driven viral evolution). These mutations may reduce the effectiveness of the specific neutralizing immune response against the virus. We provide here evidence that apart from the selection of SARS-CoV-2 variants by the immune system, selection by the cellular receptor can just as well select variants which escape neutralization.
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252367/full