tetano
Editor, Senior Moderator
Arch Virol. 2017 Jan 2. doi: 10.1007/s00705-016-3216-x. [Epub ahead of print]
[h=1]Porcine mast cells infected with H1N1 influenza virus release histamine and inflammatory cytokines and chemokines.[/h] Lee IH[SUP]1,[/SUP][SUP]2[/SUP], Kim HS[SUP]3[/SUP], Seo SH[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Mast cells reside in many tissues, including the lungs, and might play a role in enhancing influenza virus infections in animals. In this study, we cultured porcine mast cells from porcine bone marrow cells with IL-3 and stem cell factor to study the infectivity and activation of the 2009 pandemic H1N1 influenza virus of swine origin. Porcine mast cells were infected with H1N1 influenza virus, without the subsequent production of infectious viruses but were activated, as indicated by the release of histamines. Inflammatory cytokine- and chemokine-encoding genes, including IL-1α, IL-6, CXCL9, CXCL10, and CXCL11, were upregulated in the infected porcine mast cells. Our results suggest that mast cells could be involved in enhancing influenza-virus-mediated disease in infected animals.
[h=4]KEYWORDS:[/h] Inflammation; Influenza virus; Mast cells
PMID: 28044192 DOI: 10.1007/s00705-016-3216-x
[PubMed - as supplied by publisher]
[h=1]Porcine mast cells infected with H1N1 influenza virus release histamine and inflammatory cytokines and chemokines.[/h] Lee IH[SUP]1,[/SUP][SUP]2[/SUP], Kim HS[SUP]3[/SUP], Seo SH[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Mast cells reside in many tissues, including the lungs, and might play a role in enhancing influenza virus infections in animals. In this study, we cultured porcine mast cells from porcine bone marrow cells with IL-3 and stem cell factor to study the infectivity and activation of the 2009 pandemic H1N1 influenza virus of swine origin. Porcine mast cells were infected with H1N1 influenza virus, without the subsequent production of infectious viruses but were activated, as indicated by the release of histamines. Inflammatory cytokine- and chemokine-encoding genes, including IL-1α, IL-6, CXCL9, CXCL10, and CXCL11, were upregulated in the infected porcine mast cells. Our results suggest that mast cells could be involved in enhancing influenza-virus-mediated disease in infected animals.
[h=4]KEYWORDS:[/h] Inflammation; Influenza virus; Mast cells
PMID: 28044192 DOI: 10.1007/s00705-016-3216-x
[PubMed - as supplied by publisher]