tetano
Editor, Senior Moderator
Health Place. 2012 May 17. [Epub ahead of print]
Population-environment drivers of H5N1 avian influenza molecular change in Vietnam.
Carrel MA, Emch M, Nguyen T, Todd Jobe R, Wan XF.
Source
Department of Geography, University of Iowa, Iowa City, IA 52242, USA.
Abstract
This study identifies population and environment drivers of genetic change in H5N1 avian influenza viruses (AIV) in Vietnam using a landscape genetics approach. While prior work has examined how combinations of local-level environmental variables influence H5N1 occurrence, this research expands the analysis to the complex genetic characteristics of H5N1 viruses. A dataset of 125 highly pathogenic H5N1 AIV isolated in Vietnam from 2003 to 2007 is used to explore which population and environment variables are correlated with increased genetic change among viruses. Results from non-parametric multidimensional scaling and regression analyses indicate that variables relating to both the environmental and social ecology of humans and birds in Vietnam interact to affect the genetic character of viruses. These findings suggest that it is a combination of suitable environments for species mixing, the presence of high numbers of potential hosts, and in particular the temporal characteristics of viral occurrence, that drive genetic change among H5N1 AIV in Vietnam.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
22652510
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22652510
Population-environment drivers of H5N1 avian influenza molecular change in Vietnam.
Carrel MA, Emch M, Nguyen T, Todd Jobe R, Wan XF.
Source
Department of Geography, University of Iowa, Iowa City, IA 52242, USA.
Abstract
This study identifies population and environment drivers of genetic change in H5N1 avian influenza viruses (AIV) in Vietnam using a landscape genetics approach. While prior work has examined how combinations of local-level environmental variables influence H5N1 occurrence, this research expands the analysis to the complex genetic characteristics of H5N1 viruses. A dataset of 125 highly pathogenic H5N1 AIV isolated in Vietnam from 2003 to 2007 is used to explore which population and environment variables are correlated with increased genetic change among viruses. Results from non-parametric multidimensional scaling and regression analyses indicate that variables relating to both the environmental and social ecology of humans and birds in Vietnam interact to affect the genetic character of viruses. These findings suggest that it is a combination of suitable environments for species mixing, the presence of high numbers of potential hosts, and in particular the temporal characteristics of viral occurrence, that drive genetic change among H5N1 AIV in Vietnam.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
22652510
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22652510