tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2018 Jul 31. doi: 10.1097/INF.0000000000002155. [Epub ahead of print]
[h=1]Population-Based Incidence of Childhood Pneumonia Associated with Viral Infections in Bangladesh.[/h] Havers FP[SUP]1[/SUP], Fry AM[SUP]1[/SUP], Goswami D[SUP]2[/SUP], Nahar K[SUP]2[/SUP], Sharmin AT[SUP]2[/SUP], Rahman M[SUP]2[/SUP], Brooks WA[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The contribution of respiratory viruses to childhood pneumonia in tropical low- and middle-income countries is poorly understood. We used population-based respiratory illness surveillance in children <5 years old in Dhaka, Bangladesh, to characterize these illnesses.
[h=4]METHODS:[/h] We conducted weekly home visits to children who were referred to clinic for fever or respiratory symptoms. Standardized clinical data were collected. Nasopharyngeal washes were collected for one fifth of children diagnosed with a febrile or respiratory syndrome, with virus isolation testing for influenza and RT-PCR testing for other viruses. Pneumonia was defined as age-specific tachypnea and crepitations on chest auscultation by study physicians.
[h=4]RESULTS:[/h] From April 2004-February 2008, 17,584 children were followed for 17,644 child-years; 6,335 children had 12,499 clinic visits with eligible illnesses, including 6,345 pneumonia episodes (incidence of 36 episodes/100 child-years). Annual incidence of pneumonia/100 child-years ranged from 88.3 for children 0-6 months to 13.1 for those 36-60 months. Of 1,248 pneumonia visits with laboratory testing, 803 (64%) had detection of viral pathogens, including 274 respiratory syncytial virus (22% of pneumonia visits with laboratory testing; incidence 7.9/100 child-years), 244 adenovirus (19%; 7.0/100 child-years), 198 human metapneumovirus (16%; 5.7/100 child-years), 174 parainfluenza (14.0%; 5.0/100 child-years), and 81 influenza (6.5%; 2.3/100 child years).
[h=4]CONCLUSIONS:[/h] Viral pathogens contribute to a majority of childhood pneumonia episodes in Bangladesh, a setting with high pneumonia rates, especially in children <2 years old. Developing effective prevention strategies targeting these children is a high priority. Given less sensitive laboratory method used for influenza detection, influenza rates may be underestimated.
PMID: 30067597 DOI: 10.1097/INF.0000000000002155
[h=1]Population-Based Incidence of Childhood Pneumonia Associated with Viral Infections in Bangladesh.[/h] Havers FP[SUP]1[/SUP], Fry AM[SUP]1[/SUP], Goswami D[SUP]2[/SUP], Nahar K[SUP]2[/SUP], Sharmin AT[SUP]2[/SUP], Rahman M[SUP]2[/SUP], Brooks WA[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The contribution of respiratory viruses to childhood pneumonia in tropical low- and middle-income countries is poorly understood. We used population-based respiratory illness surveillance in children <5 years old in Dhaka, Bangladesh, to characterize these illnesses.
[h=4]METHODS:[/h] We conducted weekly home visits to children who were referred to clinic for fever or respiratory symptoms. Standardized clinical data were collected. Nasopharyngeal washes were collected for one fifth of children diagnosed with a febrile or respiratory syndrome, with virus isolation testing for influenza and RT-PCR testing for other viruses. Pneumonia was defined as age-specific tachypnea and crepitations on chest auscultation by study physicians.
[h=4]RESULTS:[/h] From April 2004-February 2008, 17,584 children were followed for 17,644 child-years; 6,335 children had 12,499 clinic visits with eligible illnesses, including 6,345 pneumonia episodes (incidence of 36 episodes/100 child-years). Annual incidence of pneumonia/100 child-years ranged from 88.3 for children 0-6 months to 13.1 for those 36-60 months. Of 1,248 pneumonia visits with laboratory testing, 803 (64%) had detection of viral pathogens, including 274 respiratory syncytial virus (22% of pneumonia visits with laboratory testing; incidence 7.9/100 child-years), 244 adenovirus (19%; 7.0/100 child-years), 198 human metapneumovirus (16%; 5.7/100 child-years), 174 parainfluenza (14.0%; 5.0/100 child-years), and 81 influenza (6.5%; 2.3/100 child years).
[h=4]CONCLUSIONS:[/h] Viral pathogens contribute to a majority of childhood pneumonia episodes in Bangladesh, a setting with high pneumonia rates, especially in children <2 years old. Developing effective prevention strategies targeting these children is a high priority. Given less sensitive laboratory method used for influenza detection, influenza rates may be underestimated.
PMID: 30067597 DOI: 10.1097/INF.0000000000002155