Mary Wilson
Well-known member
23 Feb 2024
BY JON COHEN
Pigs, cattle, and other livestock with edited genes are still far from most dinner plates, but a U.K. company has taken a big step toward the supermarket by engineering several commercial breeds of pigs to be resistant to a virus that devastates the swine industry. The firm, Genus plc, hopes that by year’s end the U.S. Food and Drug Administration (FDA) will formally approve the pigs for widespread human consumption, a first for a gene-edited animal. ...
Genus, which specializes in breeding livestock with desired traits, has translated “proof-of-concept work to a commercial scale,” it reports in the February issue of The CRISPR Journal. Scientists at the company modified animals in four lines of pigs that are used in commercial production of pork, by doing a CRISPR edit in early embryos that are transferred into gilts and then further breeding of the progeny. This ultimately creates breeds with both their copies of the CD163 gene disabled. ...
Some people have mild to severe allergic reactions to eating pork as a result of this sugar, and Revivicor expects GalSafe pigs will go into commercial production later this year for this specialized market. (Experimental xenotransplants of organs from GalSafe pigs have also been performed in three people who were brain-dead in the hope the sugar modification would lower the risk of rejection.) ...
https://www.science.org/content/art...ited-animals-virus-resistant-pigs-trot-toward
BY JON COHEN
Pigs, cattle, and other livestock with edited genes are still far from most dinner plates, but a U.K. company has taken a big step toward the supermarket by engineering several commercial breeds of pigs to be resistant to a virus that devastates the swine industry. The firm, Genus plc, hopes that by year’s end the U.S. Food and Drug Administration (FDA) will formally approve the pigs for widespread human consumption, a first for a gene-edited animal. ...
Genus, which specializes in breeding livestock with desired traits, has translated “proof-of-concept work to a commercial scale,” it reports in the February issue of The CRISPR Journal. Scientists at the company modified animals in four lines of pigs that are used in commercial production of pork, by doing a CRISPR edit in early embryos that are transferred into gilts and then further breeding of the progeny. This ultimately creates breeds with both their copies of the CD163 gene disabled. ...
Some people have mild to severe allergic reactions to eating pork as a result of this sugar, and Revivicor expects GalSafe pigs will go into commercial production later this year for this specialized market. (Experimental xenotransplants of organs from GalSafe pigs have also been performed in three people who were brain-dead in the hope the sugar modification would lower the risk of rejection.) ...
https://www.science.org/content/art...ited-animals-virus-resistant-pigs-trot-toward
