Giuseppe
Emeritus
[Source: PLoS Pathogens, full text: (LINK). Abstract, edited.]
Discovery of an Ebolavirus-Like Filovirus in Europe
Ana Negredo<SUP>1</SUP><SUP>#</SUP>, Gustavo Palacios<SUP>2</SUP><SUP>#</SUP><SUP>*</SUP>, Sonia V?zquez-Mor?n<SUP>1</SUP>, F?lix Gonz?lez<SUP>3</SUP>, Hern?n Dopazo<SUP>4</SUP>, Francisca Molero<SUP>1</SUP>, Javier Juste<SUP>5</SUP>, Juan Quetglas<SUP>5</SUP>, Nazir Savji<SUP>2</SUP>, Maria de la Cruz Mart?nez<SUP>1</SUP>, Jesus Enrique Herrera<SUP>2</SUP>, Manuel Pizarro<SUP>6</SUP>, Stephen K. Hutchison<SUP>7</SUP>, Juan E. Echevarr?a<SUP>1</SUP>, W. Ian Lipkin<SUP>2</SUP><SUP>?</SUP>, Antonio Tenorio<SUP>1</SUP><SUP>?</SUP>
1 National Center of Microbiology, (ISCIII), Madrid, Spain, 2 Center for Infection and Immunity, and WHO Collaborating Centre for Diagnostics, Surveillance and Immunotherapeutics for Emerging Infectious and Zoonotic Diseases, Mailman School of Public Health of Columbia University, New York, New York, United States of America, 3 Grupo Asturiano para el Estudio y Conservacion de los Murci?lagos, Posada de Llanera, Principado de Asturias, Spain, 4 Evolutionary Genomics Laboratory, Centro de Investigaci?n Pr?ncipe Felipe, Valencia, Spain, 5 Evolutionary Biology Unit, Estaci?n Biol?gica Do?ana (CSIC), Sevilla, Spain, 6 Service of Pathology, Veterinary Teaching Hospital, Veterinary School, Complutense University, Madrid, Spain, 7 Roche Life Sciences, Branford, Connecticut, United States of America
Abstract
Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease. Here we report identification in dead insectivorous bats of a genetically distinct filovirus, provisionally named Lloviu virus, after the site of detection, Cueva del Lloviu, in Spain.
Author Summary
A novel filovirus, provisionally named Lloviu virus (LLOV), was detected during the investigation of Miniopterus schreibersii die-offs in Cueva del Lloviu in southern Europe. LLOV is genetically distinct from other marburgviruses and ebolaviruses and is the first filovirus detected in Europe that was not imported from an endemic area in Africa. Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease. Here we report identification of genetically distinct filovirus in dead insectivorous bats in caves in Spain.
Citation: Negredo A, Palacios G, V?zquez-Mor?n S, Gonz?lez F, Dopazo H, et al. (2011) Discovery of an Ebolavirus-Like Filovirus in Europe. PLoS Pathog 7(10): e1002304. doi:10.1371/journal.ppat.1002304
Editor: Christopher F. Basler, Mount Sinai School of Medicine, United States of America
Received: June 15, 2011; Accepted: August 23, 2011; Published: October 20, 2011
Copyright: ? 2011 Negredo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This project was financially supported by: SAF2006-12784-C02-01, SAF2009-09172 (MEC), ?Rabies surveillance in Spain? (DGSP-MEC) and RICET Network on Tropical Diseases (ISCIII) (Spain); NIH AI57158 (NBC-Lipkin), USAID Predict (07-301-7119-52258) and the USA DOD (USA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: Stephen Hutchison is an employee at 454 Life Sciences, a division of Roche Inc.
* E-mail: gustavo.palacios@gmail.com
# These authors contributed equally to this work.
? These authors also contributed equally to this work.
- ------Ana Negredo<SUP>1</SUP><SUP>#</SUP>, Gustavo Palacios<SUP>2</SUP><SUP>#</SUP><SUP>*</SUP>, Sonia V?zquez-Mor?n<SUP>1</SUP>, F?lix Gonz?lez<SUP>3</SUP>, Hern?n Dopazo<SUP>4</SUP>, Francisca Molero<SUP>1</SUP>, Javier Juste<SUP>5</SUP>, Juan Quetglas<SUP>5</SUP>, Nazir Savji<SUP>2</SUP>, Maria de la Cruz Mart?nez<SUP>1</SUP>, Jesus Enrique Herrera<SUP>2</SUP>, Manuel Pizarro<SUP>6</SUP>, Stephen K. Hutchison<SUP>7</SUP>, Juan E. Echevarr?a<SUP>1</SUP>, W. Ian Lipkin<SUP>2</SUP><SUP>?</SUP>, Antonio Tenorio<SUP>1</SUP><SUP>?</SUP>
1 National Center of Microbiology, (ISCIII), Madrid, Spain, 2 Center for Infection and Immunity, and WHO Collaborating Centre for Diagnostics, Surveillance and Immunotherapeutics for Emerging Infectious and Zoonotic Diseases, Mailman School of Public Health of Columbia University, New York, New York, United States of America, 3 Grupo Asturiano para el Estudio y Conservacion de los Murci?lagos, Posada de Llanera, Principado de Asturias, Spain, 4 Evolutionary Genomics Laboratory, Centro de Investigaci?n Pr?ncipe Felipe, Valencia, Spain, 5 Evolutionary Biology Unit, Estaci?n Biol?gica Do?ana (CSIC), Sevilla, Spain, 6 Service of Pathology, Veterinary Teaching Hospital, Veterinary School, Complutense University, Madrid, Spain, 7 Roche Life Sciences, Branford, Connecticut, United States of America
Abstract
Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease. Here we report identification in dead insectivorous bats of a genetically distinct filovirus, provisionally named Lloviu virus, after the site of detection, Cueva del Lloviu, in Spain.
Author Summary
A novel filovirus, provisionally named Lloviu virus (LLOV), was detected during the investigation of Miniopterus schreibersii die-offs in Cueva del Lloviu in southern Europe. LLOV is genetically distinct from other marburgviruses and ebolaviruses and is the first filovirus detected in Europe that was not imported from an endemic area in Africa. Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease. Here we report identification of genetically distinct filovirus in dead insectivorous bats in caves in Spain.
Citation: Negredo A, Palacios G, V?zquez-Mor?n S, Gonz?lez F, Dopazo H, et al. (2011) Discovery of an Ebolavirus-Like Filovirus in Europe. PLoS Pathog 7(10): e1002304. doi:10.1371/journal.ppat.1002304
Editor: Christopher F. Basler, Mount Sinai School of Medicine, United States of America
Received: June 15, 2011; Accepted: August 23, 2011; Published: October 20, 2011
Copyright: ? 2011 Negredo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This project was financially supported by: SAF2006-12784-C02-01, SAF2009-09172 (MEC), ?Rabies surveillance in Spain? (DGSP-MEC) and RICET Network on Tropical Diseases (ISCIII) (Spain); NIH AI57158 (NBC-Lipkin), USAID Predict (07-301-7119-52258) and the USA DOD (USA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: Stephen Hutchison is an employee at 454 Life Sciences, a division of Roche Inc.
* E-mail: gustavo.palacios@gmail.com
# These authors contributed equally to this work.
? These authors also contributed equally to this work.