tetano
Editor, Senior Moderator
LoS One
. 2022 Aug 30;17(8):e0273712.
doi: 10.1371/journal.pone.0273712. eCollection 2022.
Neutralizing-antibody response to SARS-CoV-2 for 12 months after the COVID-19 workplace outbreaks in Japan
Azumi Ishizaki[SUP] 1 [/SUP], Xiuqiong Bi[SUP] 1 [/SUP], Quynh Thi Nguyen[SUP] 1 [/SUP], Tomomi Maeno[SUP] 2 [/SUP], Akinori Hara[SUP] 3 4 [/SUP], Hiroyuki Nakamura[SUP] 3 4 [/SUP], Sanae Kuramoto[SUP] 5 [/SUP], Koichi Nishi[SUP] 6 [/SUP], Hiroyasu Ooe[SUP] 7 [/SUP], Hiroshi Ichimura[SUP] 1 [/SUP]
Affiliations
Abstract
This study aimed to elucidate the 12-month durability of neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients infected during the 2020 workplace outbreaks of coronavirus disease 2019 (COVID-19) in Japan. We followed 33 Japanese patients infected with SARS-CoV-2 in April 2020 for 12 months (12M). Patients were tested for NAbs and for antibodies against the SARS-CoV-2 nucleocapsid (anti-NC-Ab) and antibodies against the spike receptor-binding domain (anti-RBD-Ab). Tests were performed at 2M, 6M, and 12M after the primary infection (api) with commercially available test kits. In 90.9% (30/33) of patients, NAbs persisted for 12M api, though the median titers significantly declined from 78.7% (interquartile range [IQR]: 73.0-85.0%) at 2M, to 59.8% (IQR: 51.2-77.9) at 6M (P = 0.008), and to 56.2% (IQR: 39.6-74.4) at 12M (P<0.001). An exponential decay model showed that the NAb level reached undetectable concentrations at 35.5 months api (95% confidence interval: 26.5-48.0 months). Additionally, NAb titers were significantly related to anti-RBD-Ab titers (rho = 0.736, P<0.001), but not to anti-NC-Ab titers. In most patients convalescing from COVID-19, NAbs persisted for 12M api. This result suggested that patients need a booster vaccination within one year api, even though NAbs could be detected for over two years api. Anti-RBD-Ab titers could be used as a surrogate marker for predicting residual NAb levels.
. 2022 Aug 30;17(8):e0273712.
doi: 10.1371/journal.pone.0273712. eCollection 2022.
Neutralizing-antibody response to SARS-CoV-2 for 12 months after the COVID-19 workplace outbreaks in Japan
Azumi Ishizaki[SUP] 1 [/SUP], Xiuqiong Bi[SUP] 1 [/SUP], Quynh Thi Nguyen[SUP] 1 [/SUP], Tomomi Maeno[SUP] 2 [/SUP], Akinori Hara[SUP] 3 4 [/SUP], Hiroyuki Nakamura[SUP] 3 4 [/SUP], Sanae Kuramoto[SUP] 5 [/SUP], Koichi Nishi[SUP] 6 [/SUP], Hiroyasu Ooe[SUP] 7 [/SUP], Hiroshi Ichimura[SUP] 1 [/SUP]
Affiliations
- PMID: 36040882
- DOI: 10.1371/journal.pone.0273712
Abstract
This study aimed to elucidate the 12-month durability of neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients infected during the 2020 workplace outbreaks of coronavirus disease 2019 (COVID-19) in Japan. We followed 33 Japanese patients infected with SARS-CoV-2 in April 2020 for 12 months (12M). Patients were tested for NAbs and for antibodies against the SARS-CoV-2 nucleocapsid (anti-NC-Ab) and antibodies against the spike receptor-binding domain (anti-RBD-Ab). Tests were performed at 2M, 6M, and 12M after the primary infection (api) with commercially available test kits. In 90.9% (30/33) of patients, NAbs persisted for 12M api, though the median titers significantly declined from 78.7% (interquartile range [IQR]: 73.0-85.0%) at 2M, to 59.8% (IQR: 51.2-77.9) at 6M (P = 0.008), and to 56.2% (IQR: 39.6-74.4) at 12M (P<0.001). An exponential decay model showed that the NAb level reached undetectable concentrations at 35.5 months api (95% confidence interval: 26.5-48.0 months). Additionally, NAb titers were significantly related to anti-RBD-Ab titers (rho = 0.736, P<0.001), but not to anti-NC-Ab titers. In most patients convalescing from COVID-19, NAbs persisted for 12M api. This result suggested that patients need a booster vaccination within one year api, even though NAbs could be detected for over two years api. Anti-RBD-Ab titers could be used as a surrogate marker for predicting residual NAb levels.