tetano
Editor, Senior Moderator
PLoS One
. 2022 Jun 24;17(6):e0269032.
doi: 10.1371/journal.pone.0269032. eCollection 2022.
Neutralizing antibodies levels are increased in individuals with heterologous vaccination and hybrid immunity with Ad5-nCoV in the north of Mexico
Karla Cervantes-Luevano[SUP] 1 [/SUP], Astrid N Espino-Vazquez[SUP] 1 [/SUP], Gonzalo Flores-Acosta[SUP] 1 [/SUP], Johanna Bernaldez-Sarabia[SUP] 1 [/SUP], Olivia Cabanillas-Bernal[SUP] 1 [/SUP], Jahaziel Gasperin-Bulbarela[SUP] 1 [/SUP], Ricardo Gonzalez-Sanchez[SUP] 1 [/SUP], Andreu Comas-Garcia[SUP] 2 [/SUP], Alexei F Licea-Navarro[SUP] 1 [/SUP]
Affiliations
Abstract
The coordinated efforts to stop the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) include massive immunization of the population at a global scale. The humoral immunity against COVID-19 is conferred by neutralizing antibodies (NAbs) that occur during the post-infection period and upon vaccination. Here, we provide robust data showing that potent neutralizing antibodies are induced in convalescent patients of SARS-CoV-2 infection who have been immunized with different types of vaccines, and patients with no previous history of COVID-19 immunized with a mixed vaccination schedule regardless of the previous infection. More importantly, we showed that a heterologous prime-boost in individuals with Ad5-nCoV (Cansino) vaccine induces higher NAbs levels in comparison to a single vaccination scheme alone.
. 2022 Jun 24;17(6):e0269032.
doi: 10.1371/journal.pone.0269032. eCollection 2022.
Neutralizing antibodies levels are increased in individuals with heterologous vaccination and hybrid immunity with Ad5-nCoV in the north of Mexico
Karla Cervantes-Luevano[SUP] 1 [/SUP], Astrid N Espino-Vazquez[SUP] 1 [/SUP], Gonzalo Flores-Acosta[SUP] 1 [/SUP], Johanna Bernaldez-Sarabia[SUP] 1 [/SUP], Olivia Cabanillas-Bernal[SUP] 1 [/SUP], Jahaziel Gasperin-Bulbarela[SUP] 1 [/SUP], Ricardo Gonzalez-Sanchez[SUP] 1 [/SUP], Andreu Comas-Garcia[SUP] 2 [/SUP], Alexei F Licea-Navarro[SUP] 1 [/SUP]
Affiliations
- PMID: 35749390
- DOI: 10.1371/journal.pone.0269032
Abstract
The coordinated efforts to stop the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) include massive immunization of the population at a global scale. The humoral immunity against COVID-19 is conferred by neutralizing antibodies (NAbs) that occur during the post-infection period and upon vaccination. Here, we provide robust data showing that potent neutralizing antibodies are induced in convalescent patients of SARS-CoV-2 infection who have been immunized with different types of vaccines, and patients with no previous history of COVID-19 immunized with a mixed vaccination schedule regardless of the previous infection. More importantly, we showed that a heterologous prime-boost in individuals with Ad5-nCoV (Cansino) vaccine induces higher NAbs levels in comparison to a single vaccination scheme alone.