tetano
Editor, Senior Moderator
PLoS One
. 2025 Dec 4;20(12):e0337915.
doi: 10.1371/journal.pone.0337915. eCollection 2025. Lung infection in orally inoculated SARS-CoV-2 hamsters
Evelyne Picard-Meyer[SUP] 1 [/SUP], Marine Wasniewski[SUP] 1 [/SUP], Franck Boué[SUP] 1 [/SUP], Edgar Torres-Maravilla[SUP] 1 2 3 [/SUP], Vinciane Saint-Criq[SUP] 2 [/SUP], Thibaut Larcher[SUP] 4 [/SUP], Kevyn Beissat[SUP] 1 5 [/SUP], Elsa Jacouton[SUP] 6 [/SUP], Sophie Holowacz[SUP] 6 [/SUP], Anne-Judith Waligora-Dupriet[SUP] 3 [/SUP], Philippe Langella[SUP] 2 [/SUP], Alexandre Servat[SUP] 7 [/SUP], Elodie Monchatre-Leroy[SUP] 8 [/SUP]
Affiliations
The digestive tropism of SARS-CoV-2 due to the presence of the same ACE2 receptor in the digestive system as in the respiratory system raised the question of the role of fecal-oral transmission in the pandemic. The aim of this study was to explore oral infection in hamsters model. SARS-CoV-2 inoculation via the oral and intranasal routes resulted in comparable infection in hamsters. In addition to implications for human health, oral infection could have implications for potential animal reservoirs.
. 2025 Dec 4;20(12):e0337915.
doi: 10.1371/journal.pone.0337915. eCollection 2025. Lung infection in orally inoculated SARS-CoV-2 hamsters
Evelyne Picard-Meyer[SUP] 1 [/SUP], Marine Wasniewski[SUP] 1 [/SUP], Franck Boué[SUP] 1 [/SUP], Edgar Torres-Maravilla[SUP] 1 2 3 [/SUP], Vinciane Saint-Criq[SUP] 2 [/SUP], Thibaut Larcher[SUP] 4 [/SUP], Kevyn Beissat[SUP] 1 5 [/SUP], Elsa Jacouton[SUP] 6 [/SUP], Sophie Holowacz[SUP] 6 [/SUP], Anne-Judith Waligora-Dupriet[SUP] 3 [/SUP], Philippe Langella[SUP] 2 [/SUP], Alexandre Servat[SUP] 7 [/SUP], Elodie Monchatre-Leroy[SUP] 8 [/SUP]
Affiliations
- PMID: 41343436
- DOI: 10.1371/journal.pone.0337915
The digestive tropism of SARS-CoV-2 due to the presence of the same ACE2 receptor in the digestive system as in the respiratory system raised the question of the role of fecal-oral transmission in the pandemic. The aim of this study was to explore oral infection in hamsters model. SARS-CoV-2 inoculation via the oral and intranasal routes resulted in comparable infection in hamsters. In addition to implications for human health, oral infection could have implications for potential animal reservoirs.