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PLoS ONE. Evolution of Scaling Emergence in Large-Scale Spatial Epidemic Spreading

Giuseppe

Emeritus
[Source: PLoS ONE, full text: (LINK). Abstract, edited.]

Evolution of Scaling Emergence in Large-Scale Spatial Epidemic Spreading



Lin Wang et al.

by Lin Wang, Xiang Li, Yi-Qing Zhang, Yan Zhang, Kan Zhang


Background

Zipf's law and Heaps' law are two representatives of the scaling concepts, which play a significant role in the study of complexity science. The coexistence of the Zipf's law and the Heaps' law motivates different understandings on the dependence between these two scalings, which has still hardly been clarified.


Methodology/Principal Findings

In this article, we observe an evolution process of the scalings: the Zipf's law and the Heaps' law are naturally shaped to coexist at the initial time, while the crossover comes with the emergence of their inconsistency at the larger time before reaching a stable state, where the Heaps' law still exists with the disappearance of strict Zipf's law. Such findings are illustrated with a scenario of large-scale spatial epidemic spreading, and the empirical results of pandemic disease support a universal analysis of the relation between the two laws regardless of the biological details of disease. Employing the United States domestic air transportation and demographic data to construct a metapopulation model for simulating the pandemic spread at the U.S. country level, we uncover that the broad heterogeneity of the infrastructure plays a key role in the evolution of scaling emergence.


Conclusions/Significance
The analyses of large-scale spatial epidemic spreading help understand the temporal evolution of scalings, indicating the coexistence of the Zipf's law and the Heaps' law depends on the collective dynamics of epidemic processes, and the heterogeneity of epidemic spread indicates the significance of performing targeted containment strategies at the early time of a pandemic disease.

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Re: PLoS ONE. Evolution of Scaling Emergence in Large-Scale Spatial Epidemic Spreading

and from the discussion in the full article . . . .

In summary, our study suggests that the analysis of large-scale spatial epidemic spread as a promising new perspective to understand the temporal evolution of the scalings. The unprecedented amount of information encoded in the empirical data of pandemic spreading provides us a rich environment to unveil the intrinsic mechanisms of scaling emergence. The heterogeneity of epidemic spread uncovered by the metapopulation model indicates the significance of performing targeted containment strategies, e.g. vaccination of prior groups, targeted antiviral prophylaxis, at the early time of a pandemic disease.
 
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