tetano
Editor, Senior Moderator
PLoS One
. 2026 Jan 12;21(1):e0340768.
doi: 10.1371/journal.pone.0340768. eCollection 2026. Evaluation of cerebrovascular reactivity using transcranial Doppler in patients with influenza
Ana Orsolic Beslic[SUP] 1 [/SUP], Kresimir Caljkusic[SUP] 2 3 [/SUP], Antonela Matana[SUP] 4 [/SUP], Katarina Tomelic Ercegovic[SUP] 5 [/SUP], Mirela Pavicic Ivelja[SUP] 1 3 4 [/SUP]
Affiliations
Influenza is primarily a respiratory disease but can cause a broad spectrum of complications, including those affecting the cerebrovascular system. The aim of this study was to evaluate cerebrovascular reactivity in patients during and after influenza infection. A total of 92 participants, mean age 43 years, were enrolled; 46 patients with confirmed influenza infection and 46 healthy controls. Cerebrovascular reactivity was assessed using transcranial Doppler in combination with the breath-holding test and quantified by the breath-holding index (BHI). The influenza group demonstrated significantly lower cerebral blood flow velocities in the middle cerebral artery both at rest (PSVrest, MVrest, p < 0.001) and after the breath-holding test (PSVmax, MVmax, p < 0.001) compared to healthy controls. The BHI was also significantly reduced in the influenza group (p < 0.001), indicating impaired cerebrovascular reactivity. Among participants reassessed three months post-recovery, blood flow velocities after the breath-holding test were significantly higher than during the acute phase (PSVmax, MVmax, p < 0.001), and BHI also improved (p < 0.001), suggesting restoration of cerebrovascular function. These findings suggest that influenza may transiently impair cerebrovascular reactivity, providing new insights into potential mechanisms influencing cerebrovascular function and hemodynamics.
. 2026 Jan 12;21(1):e0340768.
doi: 10.1371/journal.pone.0340768. eCollection 2026. Evaluation of cerebrovascular reactivity using transcranial Doppler in patients with influenza
Ana Orsolic Beslic[SUP] 1 [/SUP], Kresimir Caljkusic[SUP] 2 3 [/SUP], Antonela Matana[SUP] 4 [/SUP], Katarina Tomelic Ercegovic[SUP] 5 [/SUP], Mirela Pavicic Ivelja[SUP] 1 3 4 [/SUP]
Affiliations
- PMID: 41525289
- PMCID: PMC12795361
- DOI: 10.1371/journal.pone.0340768
Influenza is primarily a respiratory disease but can cause a broad spectrum of complications, including those affecting the cerebrovascular system. The aim of this study was to evaluate cerebrovascular reactivity in patients during and after influenza infection. A total of 92 participants, mean age 43 years, were enrolled; 46 patients with confirmed influenza infection and 46 healthy controls. Cerebrovascular reactivity was assessed using transcranial Doppler in combination with the breath-holding test and quantified by the breath-holding index (BHI). The influenza group demonstrated significantly lower cerebral blood flow velocities in the middle cerebral artery both at rest (PSVrest, MVrest, p < 0.001) and after the breath-holding test (PSVmax, MVmax, p < 0.001) compared to healthy controls. The BHI was also significantly reduced in the influenza group (p < 0.001), indicating impaired cerebrovascular reactivity. Among participants reassessed three months post-recovery, blood flow velocities after the breath-holding test were significantly higher than during the acute phase (PSVmax, MVmax, p < 0.001), and BHI also improved (p < 0.001), suggesting restoration of cerebrovascular function. These findings suggest that influenza may transiently impair cerebrovascular reactivity, providing new insights into potential mechanisms influencing cerebrovascular function and hemodynamics.