tetano
Editor, Senior Moderator
PLoS One
. 2023 Dec 15;18(12):e0295540.
doi: 10.1371/journal.pone.0295540. eCollection 2023. Effect of influenza vaccination on resting metabolic rate and c-reactive protein concentrations in healthy young adults
Claire Hagan Parker[SUP] 1 [/SUP], Srishti Sadhir[SUP] 1 [/SUP], Zane Swanson[SUP] 2 [/SUP], Amanda McGrosky[SUP] 1 [/SUP], Elena Hinz[SUP] 1 [/SUP], Samuel S Urlacher[SUP] 3 4 [/SUP], Herman Pontzer[SUP] 1 5 [/SUP]
Affiliations
Objectives: Chronic immune activation and severe inflammatory states are positively associated with resting metabolic rate (RMR; kcal/day), but the impacts of mild immune stimuli on metabolism are poorly understood. This study investigates the within-individual association between the inflammatory response to influenza vaccination and RMR in young adults.
Methods: We evaluated RMRs through indirect calorimetry and circulating c-reactive protein (CRP) concentrations (mg/L)-a direct measure of inflammation-via high-sensitivity immunoassays of dried blood spots (n = 17) at baseline and two- and seven-days post-vaccine. Wilcoxon matched-pairs signed-rank tests were used to evaluate the magnitude of the CRP and RMR responses. Type II Wald chi-square tests of linear mixed-effect models assessed whether those responses were correlated.
Results: Baseline CRP was 1.39 ± 1.26 mg/L. On day two post-vaccine, CRP increased by 1.47 ± 1.37 mg/L (p < 0.0001), representing a 106% increase above baseline values. CRP remained higher on day seven post-vaccine, 1.32 ± 2.47 mg/L (p = 0.05) above baseline values. There were no statistically significant changes in RMR from baseline to day two (p = 0.98) or day seven (p = 0.21). Change in CRP from baseline did not predict RMR variation across days (p = 0.46).
Conclusions: We find no evidence that adult influenza vaccination results in a corresponding increase in RMR. These results suggest that the energetic cost of an influenza vaccine's mild inflammatory stimulus is either too small to detect or is largely compensated by a temporary downregulation of energy allocated to other metabolic tasks.
. 2023 Dec 15;18(12):e0295540.
doi: 10.1371/journal.pone.0295540. eCollection 2023. Effect of influenza vaccination on resting metabolic rate and c-reactive protein concentrations in healthy young adults
Claire Hagan Parker[SUP] 1 [/SUP], Srishti Sadhir[SUP] 1 [/SUP], Zane Swanson[SUP] 2 [/SUP], Amanda McGrosky[SUP] 1 [/SUP], Elena Hinz[SUP] 1 [/SUP], Samuel S Urlacher[SUP] 3 4 [/SUP], Herman Pontzer[SUP] 1 5 [/SUP]
Affiliations
- PMID: 38100425
- DOI: 10.1371/journal.pone.0295540
Objectives: Chronic immune activation and severe inflammatory states are positively associated with resting metabolic rate (RMR; kcal/day), but the impacts of mild immune stimuli on metabolism are poorly understood. This study investigates the within-individual association between the inflammatory response to influenza vaccination and RMR in young adults.
Methods: We evaluated RMRs through indirect calorimetry and circulating c-reactive protein (CRP) concentrations (mg/L)-a direct measure of inflammation-via high-sensitivity immunoassays of dried blood spots (n = 17) at baseline and two- and seven-days post-vaccine. Wilcoxon matched-pairs signed-rank tests were used to evaluate the magnitude of the CRP and RMR responses. Type II Wald chi-square tests of linear mixed-effect models assessed whether those responses were correlated.
Results: Baseline CRP was 1.39 ± 1.26 mg/L. On day two post-vaccine, CRP increased by 1.47 ± 1.37 mg/L (p < 0.0001), representing a 106% increase above baseline values. CRP remained higher on day seven post-vaccine, 1.32 ± 2.47 mg/L (p = 0.05) above baseline values. There were no statistically significant changes in RMR from baseline to day two (p = 0.98) or day seven (p = 0.21). Change in CRP from baseline did not predict RMR variation across days (p = 0.46).
Conclusions: We find no evidence that adult influenza vaccination results in a corresponding increase in RMR. These results suggest that the energetic cost of an influenza vaccine's mild inflammatory stimulus is either too small to detect or is largely compensated by a temporary downregulation of energy allocated to other metabolic tasks.