tetano
Editor, Senior Moderator
PLoS One
. 2020 Oct 30;15(10):e0240751.
doi: 10.1371/journal.pone.0240751. eCollection 2020.
Effect of blood analysis and immune function on the prognosis of patients with COVID-19
Yue-Qiang Fu[SUP] 1 2 3 4 [/SUP], Yue-Lin Sun[SUP] 1 3 4 [/SUP], Si-Wei Lu[SUP] 1 3 4 [/SUP], Yang Yang[SUP] 5 [/SUP], Yi Wang[SUP] 1 2 3 4 [/SUP], Feng Xu[SUP] 1 3 4 [/SUP]
Affiliations
Abstract
Introduction: This retrospective study investigated the implications of changes in blood parameters and cellular immune function in patients with Coronavirus Disease 2019 (COVID-19).
Methods: Records were reviewed of 85 patients admitted with COVID-19 between February 4 and 16, 2020. The primary outcome was in-hospital death.
Results: Fourteen patients died. The baseline leukocyte count, neutrophil count and hemoglobin was significantly higher in non-survivors compared with survivors, while the reverse was true of lymphocyte count, platelet, PaO2/FiO2, CD3+ count and CD4+ count. The percentage of neutrophil count > 6.3?109/L in death group was significantly higher than that in survival group, and multivariate logistic regression showed neutrophil count > 6.3?109/L was independently associated with mortality. However, there were not significant difference in IgG, IgM, IgA, C3, C4 and the percentage of IgE > 100 IU/ml between the death group and survival group. Areas under the receiver operating characteristic curves of the following at baseline could significantly predict mortality: leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts.
Conclusions: For hospitalized patients with COVID-19, lymphocyte, CD3+ and CD4+ counts that marked decrease suggest a poor outcome. Admission neutrophil count > 6.3 ?109/L is independently associated with mortality. At admission, leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts should receive added attention.
. 2020 Oct 30;15(10):e0240751.
doi: 10.1371/journal.pone.0240751. eCollection 2020.
Effect of blood analysis and immune function on the prognosis of patients with COVID-19
Yue-Qiang Fu[SUP] 1 2 3 4 [/SUP], Yue-Lin Sun[SUP] 1 3 4 [/SUP], Si-Wei Lu[SUP] 1 3 4 [/SUP], Yang Yang[SUP] 5 [/SUP], Yi Wang[SUP] 1 2 3 4 [/SUP], Feng Xu[SUP] 1 3 4 [/SUP]
Affiliations
- PMID: 33125396
- DOI: 10.1371/journal.pone.0240751
Abstract
Introduction: This retrospective study investigated the implications of changes in blood parameters and cellular immune function in patients with Coronavirus Disease 2019 (COVID-19).
Methods: Records were reviewed of 85 patients admitted with COVID-19 between February 4 and 16, 2020. The primary outcome was in-hospital death.
Results: Fourteen patients died. The baseline leukocyte count, neutrophil count and hemoglobin was significantly higher in non-survivors compared with survivors, while the reverse was true of lymphocyte count, platelet, PaO2/FiO2, CD3+ count and CD4+ count. The percentage of neutrophil count > 6.3?109/L in death group was significantly higher than that in survival group, and multivariate logistic regression showed neutrophil count > 6.3?109/L was independently associated with mortality. However, there were not significant difference in IgG, IgM, IgA, C3, C4 and the percentage of IgE > 100 IU/ml between the death group and survival group. Areas under the receiver operating characteristic curves of the following at baseline could significantly predict mortality: leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts.
Conclusions: For hospitalized patients with COVID-19, lymphocyte, CD3+ and CD4+ counts that marked decrease suggest a poor outcome. Admission neutrophil count > 6.3 ?109/L is independently associated with mortality. At admission, leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts should receive added attention.