tetano
Editor, Senior Moderator
PLoS One
. 2024 Dec 20;19(12):e0316213.
doi: 10.1371/journal.pone.0316213. eCollection 2024. Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022
Hiie Soeorg[SUP] 1 2 [/SUP], Aare Abroi[SUP] 3 [/SUP], Taavi Päll[SUP] 1 [/SUP], Liidia Dotsenko[SUP] 4 [/SUP], Erik Jaaniso[SUP] 5 [/SUP], Katrin Kaarna[SUP] 6 7 [/SUP], Andrio Lahesaare[SUP] 8 [/SUP], Paul Naaber[SUP] 1 8 [/SUP], Heiki Niglas[SUP] 4 [/SUP], Ott Eric Oopkaup[SUP] 9 [/SUP], Hedi Peterson[SUP] 5 [/SUP], Tuuli Reisberg[SUP] 10 [/SUP], Olga Sadikova[SUP] 4 [/SUP], Steven Smit[SUP] 10 [/SUP], Ulvi Gerst Talas[SUP] 9 [/SUP], Radko Avi[SUP] 1 [/SUP], Irja Lutsar[SUP] 1 [/SUP], Kristi Huik[SUP] 1 [/SUP]
Affiliations
Purpose: We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries.
Methods: SARS-CoV-2 sequences in 2021-2022 from a nationwide study were included. The proportion of predominant lineages in Estonian regions and among travel-related cases was described by multinomial logistic regression. Simpson's indices of diversity were compared using linear regression. Dynamics of Bray-Curtis dissimilarity was described by applying fuzzy clustering to non-metrical dimensional scaling results.
Results: A total of 2,630 sequences from children (<15 years) and 23,031 from adults (≥15 years) were included. The increase in the proportion of Alpha/Delta/Omicron BA.1/BA.2 lineages was delayed in smaller regions (by 3.5-27.5 days). The proportion of Alpha/Delta/Omicron BA.1 increased earlier among travel-related (n = 4,654) than non-travel-related cases (10.5 days). Diversity was lower in non-travel-related than travel-related cases until Delta period by 0.066. Dynamics of lineages and diversity were similar in adults and children. Similarity of lineages was delayed compared to Finland during Alpha/Omicron BA.1/BA.2 periods and different from all neighbouring countries during Delta period.
Conclusion: SARS-CoV-2 lineages in children and adults were similar. Differences between regions and travel-related cases and varying similarity to neighbouring countries suggest the importance of mobility in the spread.
. 2024 Dec 20;19(12):e0316213.
doi: 10.1371/journal.pone.0316213. eCollection 2024. Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022
Hiie Soeorg[SUP] 1 2 [/SUP], Aare Abroi[SUP] 3 [/SUP], Taavi Päll[SUP] 1 [/SUP], Liidia Dotsenko[SUP] 4 [/SUP], Erik Jaaniso[SUP] 5 [/SUP], Katrin Kaarna[SUP] 6 7 [/SUP], Andrio Lahesaare[SUP] 8 [/SUP], Paul Naaber[SUP] 1 8 [/SUP], Heiki Niglas[SUP] 4 [/SUP], Ott Eric Oopkaup[SUP] 9 [/SUP], Hedi Peterson[SUP] 5 [/SUP], Tuuli Reisberg[SUP] 10 [/SUP], Olga Sadikova[SUP] 4 [/SUP], Steven Smit[SUP] 10 [/SUP], Ulvi Gerst Talas[SUP] 9 [/SUP], Radko Avi[SUP] 1 [/SUP], Irja Lutsar[SUP] 1 [/SUP], Kristi Huik[SUP] 1 [/SUP]
Affiliations
- PMID: 39705295
- PMCID: PMC11661589
- DOI: 10.1371/journal.pone.0316213
Purpose: We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries.
Methods: SARS-CoV-2 sequences in 2021-2022 from a nationwide study were included. The proportion of predominant lineages in Estonian regions and among travel-related cases was described by multinomial logistic regression. Simpson's indices of diversity were compared using linear regression. Dynamics of Bray-Curtis dissimilarity was described by applying fuzzy clustering to non-metrical dimensional scaling results.
Results: A total of 2,630 sequences from children (<15 years) and 23,031 from adults (≥15 years) were included. The increase in the proportion of Alpha/Delta/Omicron BA.1/BA.2 lineages was delayed in smaller regions (by 3.5-27.5 days). The proportion of Alpha/Delta/Omicron BA.1 increased earlier among travel-related (n = 4,654) than non-travel-related cases (10.5 days). Diversity was lower in non-travel-related than travel-related cases until Delta period by 0.066. Dynamics of lineages and diversity were similar in adults and children. Similarity of lineages was delayed compared to Finland during Alpha/Omicron BA.1/BA.2 periods and different from all neighbouring countries during Delta period.
Conclusion: SARS-CoV-2 lineages in children and adults were similar. Differences between regions and travel-related cases and varying similarity to neighbouring countries suggest the importance of mobility in the spread.