tetano
Editor, Senior Moderator
PLoS One
. 2020 Nov 4;15(11):e0241896.
doi: 10.1371/journal.pone.0241896. eCollection 2020.
Clinical characteristics of re-positive COVID-19 patients in Huangshi, China: A retrospective cohort study
Ji Zhou[SUP] 1 2 [/SUP], Jingying Zhang[SUP] 1 3 [/SUP], Juan Zhou[SUP] 1 4 [/SUP], Honggang Yi[SUP] 5 [/SUP], Zichen Lin[SUP] 6 [/SUP], Yu Liu[SUP] 7 [/SUP], Min Zhu[SUP] 6 [/SUP], Hongyu Wang[SUP] 6 [/SUP], Wei Zhang[SUP] 8 [/SUP], Hai Xu[SUP] 8 [/SUP], Hangping Jiang[SUP] 9 [/SUP], Zhengzhong Xiang[SUP] 10 [/SUP], Ze Qu[SUP] 11 [/SUP], Yuemei Yang[SUP] 6 [/SUP], Linjuan Lu[SUP] 6 [/SUP], Shuai Guo[SUP] 6 [/SUP], Heng Fu[SUP] 6 [/SUP], Ian M Adcock[SUP] 12 [/SUP], Yu Wei[SUP] 3 [/SUP], Xin Yao[SUP] 1 2 [/SUP]
Affiliations
Abstract
A cluster of patients with coronavirus disease 2019 (COVID-19) underwent repeated positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA tests after they were discharged from the hospital. We referred to them as re-positive (RP) patients in this study. We aimed to describe the clinical characteristics of these patients in a retrospective cohort study. After being treated for COVID-19, the patients underwent 14 days of quarantine following their discharge from the Huangshi Hospital of Traditional Chinese Medicine and the Huangshi Hospital of Youse. Two additional sequential SARS-CoV-2 RNA tests were performed at the end of quarantine. The median age of the 368 patients was 51 years, and 184 (50%) patients were female. A total of 23 RP patients were observed at follow-up. Using multivariate Cox regression analysis, risk factors associated with RP included a higher ratio of lymphocyte/white blood cell on admission (adjusted HR 7.038; 95% CI, 1.911-25.932; P = 0.0034), lower peak temperature during hospitalization (adjusted HR, 0.203; 95% CI, 0.093-0.443; P<0.0001), and the presence of comorbidities, particularly hypertension or chronic diseases in the respiratory system (adjusted HR, 3.883; 95% CI, 1.468-10.273; P = 0.0063). Antivirus treatment with arbidol was associated with a lower likelihood of re-positive outcomes (adjusted HR, 0.178; 95% CI, 0.045-0.709; P = 0.0144).
. 2020 Nov 4;15(11):e0241896.
doi: 10.1371/journal.pone.0241896. eCollection 2020.
Clinical characteristics of re-positive COVID-19 patients in Huangshi, China: A retrospective cohort study
Ji Zhou[SUP] 1 2 [/SUP], Jingying Zhang[SUP] 1 3 [/SUP], Juan Zhou[SUP] 1 4 [/SUP], Honggang Yi[SUP] 5 [/SUP], Zichen Lin[SUP] 6 [/SUP], Yu Liu[SUP] 7 [/SUP], Min Zhu[SUP] 6 [/SUP], Hongyu Wang[SUP] 6 [/SUP], Wei Zhang[SUP] 8 [/SUP], Hai Xu[SUP] 8 [/SUP], Hangping Jiang[SUP] 9 [/SUP], Zhengzhong Xiang[SUP] 10 [/SUP], Ze Qu[SUP] 11 [/SUP], Yuemei Yang[SUP] 6 [/SUP], Linjuan Lu[SUP] 6 [/SUP], Shuai Guo[SUP] 6 [/SUP], Heng Fu[SUP] 6 [/SUP], Ian M Adcock[SUP] 12 [/SUP], Yu Wei[SUP] 3 [/SUP], Xin Yao[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33147282
- DOI: 10.1371/journal.pone.0241896
Abstract
A cluster of patients with coronavirus disease 2019 (COVID-19) underwent repeated positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA tests after they were discharged from the hospital. We referred to them as re-positive (RP) patients in this study. We aimed to describe the clinical characteristics of these patients in a retrospective cohort study. After being treated for COVID-19, the patients underwent 14 days of quarantine following their discharge from the Huangshi Hospital of Traditional Chinese Medicine and the Huangshi Hospital of Youse. Two additional sequential SARS-CoV-2 RNA tests were performed at the end of quarantine. The median age of the 368 patients was 51 years, and 184 (50%) patients were female. A total of 23 RP patients were observed at follow-up. Using multivariate Cox regression analysis, risk factors associated with RP included a higher ratio of lymphocyte/white blood cell on admission (adjusted HR 7.038; 95% CI, 1.911-25.932; P = 0.0034), lower peak temperature during hospitalization (adjusted HR, 0.203; 95% CI, 0.093-0.443; P<0.0001), and the presence of comorbidities, particularly hypertension or chronic diseases in the respiratory system (adjusted HR, 3.883; 95% CI, 1.468-10.273; P = 0.0063). Antivirus treatment with arbidol was associated with a lower likelihood of re-positive outcomes (adjusted HR, 0.178; 95% CI, 0.045-0.709; P = 0.0144).