tetano
Editor, Senior Moderator
PLoS One
. 2022 Aug 23;17(8):e0273150.
doi: 10.1371/journal.pone.0273150. eCollection 2022.
Clinical characteristics of patients with confirmed and asymptomatic SARS-CoV-2 infection in China
Zongren Li[SUP] 1 2 [/SUP], Qin Zhong[SUP] 2 [/SUP], Wenyuan Li[SUP] 3 [/SUP], Dawei Zhang[SUP] 4 [/SUP], Wenjun Wang[SUP] 5 [/SUP], Feifei Yang[SUP] 6 [/SUP], Kunlun He[SUP] 1 2 5 [/SUP]
Affiliations
Abstract
Objective: To examine the clinical characteristics of patients with asymptomatic novel coronavirus disease 2019 (COVID-19) and compare them with those of patients with mild disease.
Design: A retrospective cohort study.
Setting: Multiple medical centers in Wuhan, Hubei, China.
Participants: A total of 3,263 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection between February 4, 2020, and April 15, 2020.
Main outcome measures: Patient demographic characteristics, medical history, vital signs, and laboratory and chest computed tomography (CT) findings.
Results: A total of 3,173 and 90 patients with mild and moderate, and asymptomatic COVID-19, respectively, were included. A total of 575 (18.2%) symptomatic patients and 4 (4.4%) asymptomatic patients developed the severe illness. All asymptomatic patients recovered; no deaths were observed in this group. The median duration of viral shedding in asymptomatic patients was 17 (interquartile range, 9.25-25) days. Patients with higher levels of ultrasensitive C-reactive protein (odds ratio [OR] = 1.025, 95% confidence interval [CI], 1.01-1.04), lower red blood cell volume distribution width (OR = 0.68, 95% CI 0.51-0.88), lower creatine kinase Isoenzyme(0.94, 0.89-0.98) levels, or lower lesion ratio (OR = 0.01, 95% CI 0.00-0.33) at admission were more likely than their counterparts to have asymptomatic disease.
Conclusions: Patients with younger ages and fewer comorbidities are more likely to be asymptomatic. Asymptomatic patients had similar laboratory characteristics and longer virus shedding time than symptomatic patients; screen and isolation during their infection were helpful to reduce the risk of SARS-CoV-2 transmission.
. 2022 Aug 23;17(8):e0273150.
doi: 10.1371/journal.pone.0273150. eCollection 2022.
Clinical characteristics of patients with confirmed and asymptomatic SARS-CoV-2 infection in China
Zongren Li[SUP] 1 2 [/SUP], Qin Zhong[SUP] 2 [/SUP], Wenyuan Li[SUP] 3 [/SUP], Dawei Zhang[SUP] 4 [/SUP], Wenjun Wang[SUP] 5 [/SUP], Feifei Yang[SUP] 6 [/SUP], Kunlun He[SUP] 1 2 5 [/SUP]
Affiliations
- PMID: 35998155
- DOI: 10.1371/journal.pone.0273150
Abstract
Objective: To examine the clinical characteristics of patients with asymptomatic novel coronavirus disease 2019 (COVID-19) and compare them with those of patients with mild disease.
Design: A retrospective cohort study.
Setting: Multiple medical centers in Wuhan, Hubei, China.
Participants: A total of 3,263 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection between February 4, 2020, and April 15, 2020.
Main outcome measures: Patient demographic characteristics, medical history, vital signs, and laboratory and chest computed tomography (CT) findings.
Results: A total of 3,173 and 90 patients with mild and moderate, and asymptomatic COVID-19, respectively, were included. A total of 575 (18.2%) symptomatic patients and 4 (4.4%) asymptomatic patients developed the severe illness. All asymptomatic patients recovered; no deaths were observed in this group. The median duration of viral shedding in asymptomatic patients was 17 (interquartile range, 9.25-25) days. Patients with higher levels of ultrasensitive C-reactive protein (odds ratio [OR] = 1.025, 95% confidence interval [CI], 1.01-1.04), lower red blood cell volume distribution width (OR = 0.68, 95% CI 0.51-0.88), lower creatine kinase Isoenzyme(0.94, 0.89-0.98) levels, or lower lesion ratio (OR = 0.01, 95% CI 0.00-0.33) at admission were more likely than their counterparts to have asymptomatic disease.
Conclusions: Patients with younger ages and fewer comorbidities are more likely to be asymptomatic. Asymptomatic patients had similar laboratory characteristics and longer virus shedding time than symptomatic patients; screen and isolation during their infection were helpful to reduce the risk of SARS-CoV-2 transmission.