tetano
Editor, Senior Moderator
PLoS One
. 2021 Apr 29;16(4):e0250330.
doi: 10.1371/journal.pone.0250330. eCollection 2021.
Analysis of cytokines in SARS-CoV-2 or COVID-19 patients in Erbil city, Kurdistan Region of Iraq
Mohammed Yousif Merza[SUP] 1 2 [/SUP], Rundk Ahmed Hwaiz[SUP] 2 3 [/SUP], Badraldin Kareem Hamad[SUP] 1 [/SUP], Karzan Abdulmuhsin Mohammad[SUP] 4 5 [/SUP], Harmand Ali Hama[SUP] 6 [/SUP], Abdulkarim Yasin Karim[SUP] 2 7 [/SUP]
Affiliations
Abstract
The emergence of the novel coronavirus and then pandemic outbreak was coined 2019- nCoV or COVID-19 (or SARS-CoV-2 disease 2019). This disease has a mortality rate of about 3?7 percent, and successful therapy is desperately needed to combat it. The exact cellular mechanisms of COVID-19 need to be illustrated in detail. This study aimed to evaluate serum cytokines in COVID-19 patients. In this study, serum was collected from volunteer individuals, moderate COVID-19 patients, severe cases of COVID-19 patients, and patients who recovered from COVID-19 (n = 122). The serum concentrations of interleukins such as IL-1, IL-4, IL-6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-?), were measured by enzyme-linked immunosorbent assays (ELISA). The concentrations of IL-1 and TNF-? were did not differ significantly among groups. However, the concentration of IL-6 was significantly higher in moderate COVID-19 and severe cases of COVID-19 groups compared to control and recovered groups indicating it to be an independent predictor in the coronavirus disease. The levels of IFN-? and IL-4 were significantly lower in the recovery group than the severe case of the COVID-19 group. In contrast, the level of IL-10 in recovered COVID-19 patients was significantly higher in compare to severe cases, COVID-19 patients. Varying levels of cytokines were detected in COVID-19 group than control group suggesting distinct immunoregulatory mechanisms involved in COVID-19 pathogenesis. However, additional investigations are needed to be to be performed to understand the exact cellular mechanism of this disease.
. 2021 Apr 29;16(4):e0250330.
doi: 10.1371/journal.pone.0250330. eCollection 2021.
Analysis of cytokines in SARS-CoV-2 or COVID-19 patients in Erbil city, Kurdistan Region of Iraq
Mohammed Yousif Merza[SUP] 1 2 [/SUP], Rundk Ahmed Hwaiz[SUP] 2 3 [/SUP], Badraldin Kareem Hamad[SUP] 1 [/SUP], Karzan Abdulmuhsin Mohammad[SUP] 4 5 [/SUP], Harmand Ali Hama[SUP] 6 [/SUP], Abdulkarim Yasin Karim[SUP] 2 7 [/SUP]
Affiliations
- PMID: 33914789
- DOI: 10.1371/journal.pone.0250330
Abstract
The emergence of the novel coronavirus and then pandemic outbreak was coined 2019- nCoV or COVID-19 (or SARS-CoV-2 disease 2019). This disease has a mortality rate of about 3?7 percent, and successful therapy is desperately needed to combat it. The exact cellular mechanisms of COVID-19 need to be illustrated in detail. This study aimed to evaluate serum cytokines in COVID-19 patients. In this study, serum was collected from volunteer individuals, moderate COVID-19 patients, severe cases of COVID-19 patients, and patients who recovered from COVID-19 (n = 122). The serum concentrations of interleukins such as IL-1, IL-4, IL-6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-?), were measured by enzyme-linked immunosorbent assays (ELISA). The concentrations of IL-1 and TNF-? were did not differ significantly among groups. However, the concentration of IL-6 was significantly higher in moderate COVID-19 and severe cases of COVID-19 groups compared to control and recovered groups indicating it to be an independent predictor in the coronavirus disease. The levels of IFN-? and IL-4 were significantly lower in the recovery group than the severe case of the COVID-19 group. In contrast, the level of IL-10 in recovered COVID-19 patients was significantly higher in compare to severe cases, COVID-19 patients. Varying levels of cytokines were detected in COVID-19 group than control group suggesting distinct immunoregulatory mechanisms involved in COVID-19 pathogenesis. However, additional investigations are needed to be to be performed to understand the exact cellular mechanism of this disease.