tetano
Editor, Senior Moderator
PLoS One
. 2023 Jan 4;18(1):e0266985.
doi: 10.1371/journal.pone.0266985. eCollection 2023.
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium
Bertrand Moal[SUP] 1 [/SUP], Arthur Orieux[SUP] 2 [/SUP], Thomas Ferté[SUP] 3 [/SUP], Antoine Neuraz[SUP] 4 [/SUP], Gabriel A Brat[SUP] 5 [/SUP], Paul Avillach[SUP] 5 [/SUP], Clara-Lea Bonzel[SUP] 5 [/SUP], Tianxi Cai[SUP] 5 [/SUP], Kelly Cho[SUP] 6 [/SUP], Sébastien Cossin[SUP] 7 [/SUP], Romain Griffier[SUP] 8 [/SUP], David A Hanauer[SUP] 9 [/SUP], Christian Haverkamp[SUP] 10 [/SUP], Yuk-Lam Ho[SUP] 8 [/SUP], Chuan Hong[SUP] 5 [/SUP], Meghan R Hutch[SUP] 11 [/SUP], Jeffrey G Klann[SUP] 12 [/SUP], Trang T Le[SUP] 5 [/SUP], Ne Hooi Will Loh[SUP] 13 [/SUP], Yuan Luo[SUP] 14 [/SUP], Adeline Makoudjou[SUP] 15 [/SUP], Michele Morris[SUP] 5 [/SUP], Danielle L Mowery[SUP] 5 [/SUP], Karen L Olson[SUP] 16 [/SUP], Lav P Patel[SUP] 14 [/SUP], Malarkodi J Samayamuthu[SUP] 5 [/SUP], Fernando J Sanz Vidorreta[SUP] 17 [/SUP], Emily R Schriver[SUP] 18 [/SUP], Petra Schubert[SUP] 19 [/SUP], Guillaume Verdy[SUP] 1 [/SUP], Shyam Visweswaran[SUP] 5 [/SUP], Xuan Wang[SUP] 5 [/SUP], Griffin M Weber[SUP] 5 [/SUP], Zongqi Xia[SUP] 20 [/SUP], William Yuan[SUP] 5 [/SUP], Harrison G Zhang[SUP] 5 [/SUP], Daniela Zöller[SUP] 21 [/SUP], Isaac S Kohane[SUP] 5 [/SUP]; Consortium for Clinical Characterization of COVID-19 by EHR (4CE); Alexandre Boyer[SUP] 2 [/SUP], Vianney Jouhet[SUP] 8 [/SUP]
Affiliations
Abstract
Purpose: In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population.
Methods: A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS.
Results: Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%).
Conclusion: Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.
. 2023 Jan 4;18(1):e0266985.
doi: 10.1371/journal.pone.0266985. eCollection 2023.
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium
Bertrand Moal[SUP] 1 [/SUP], Arthur Orieux[SUP] 2 [/SUP], Thomas Ferté[SUP] 3 [/SUP], Antoine Neuraz[SUP] 4 [/SUP], Gabriel A Brat[SUP] 5 [/SUP], Paul Avillach[SUP] 5 [/SUP], Clara-Lea Bonzel[SUP] 5 [/SUP], Tianxi Cai[SUP] 5 [/SUP], Kelly Cho[SUP] 6 [/SUP], Sébastien Cossin[SUP] 7 [/SUP], Romain Griffier[SUP] 8 [/SUP], David A Hanauer[SUP] 9 [/SUP], Christian Haverkamp[SUP] 10 [/SUP], Yuk-Lam Ho[SUP] 8 [/SUP], Chuan Hong[SUP] 5 [/SUP], Meghan R Hutch[SUP] 11 [/SUP], Jeffrey G Klann[SUP] 12 [/SUP], Trang T Le[SUP] 5 [/SUP], Ne Hooi Will Loh[SUP] 13 [/SUP], Yuan Luo[SUP] 14 [/SUP], Adeline Makoudjou[SUP] 15 [/SUP], Michele Morris[SUP] 5 [/SUP], Danielle L Mowery[SUP] 5 [/SUP], Karen L Olson[SUP] 16 [/SUP], Lav P Patel[SUP] 14 [/SUP], Malarkodi J Samayamuthu[SUP] 5 [/SUP], Fernando J Sanz Vidorreta[SUP] 17 [/SUP], Emily R Schriver[SUP] 18 [/SUP], Petra Schubert[SUP] 19 [/SUP], Guillaume Verdy[SUP] 1 [/SUP], Shyam Visweswaran[SUP] 5 [/SUP], Xuan Wang[SUP] 5 [/SUP], Griffin M Weber[SUP] 5 [/SUP], Zongqi Xia[SUP] 20 [/SUP], William Yuan[SUP] 5 [/SUP], Harrison G Zhang[SUP] 5 [/SUP], Daniela Zöller[SUP] 21 [/SUP], Isaac S Kohane[SUP] 5 [/SUP]; Consortium for Clinical Characterization of COVID-19 by EHR (4CE); Alexandre Boyer[SUP] 2 [/SUP], Vianney Jouhet[SUP] 8 [/SUP]
Affiliations
- PMID: 36598895
- DOI: 10.1371/journal.pone.0266985
Abstract
Purpose: In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population.
Methods: A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS.
Results: Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%).
Conclusion: Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.