tetano
Editor, Senior Moderator
Platelets
. 2021 Aug 13;1-9.
doi: 10.1080/09537104.2021.1962519. Online ahead of print.
Alterations in platelets during SARS-CoV-2 infection
Marta Brambilla[SUP] 1 [/SUP], Paola Canzano[SUP] 1 [/SUP], Alessia Becchetti[SUP] 1 [/SUP], Elena Tremoli[SUP] 2 [/SUP], Marina Camera[SUP] 1 3 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a pandemic syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection induces a process of inflammation and thrombosis supported by an altered platelet activation state. This platelet activation is peculiar being characterized by the formation of platelet-leukocytes rather than platelet-platelet aggregates and by an increased procoagulant potential supported by elevated levels of TF positive platelets and microvesicles.Therapeutic strategies targeting, beyond systemic inflammation (i.e. with tocilizumab, an anti interleukin-6 receptor), this state of platelet activation might therefore be beneficial. Among the antithrombotic drugs proposed as candidates to treat patients with SARS-CoV-2 infection, antiplatelet drugs, such as aspirin are showing promising results.
Keywords: Antiplatelet drugs; COVID-19; coagulation; platelets; thrombosis.
. 2021 Aug 13;1-9.
doi: 10.1080/09537104.2021.1962519. Online ahead of print.
Alterations in platelets during SARS-CoV-2 infection
Marta Brambilla[SUP] 1 [/SUP], Paola Canzano[SUP] 1 [/SUP], Alessia Becchetti[SUP] 1 [/SUP], Elena Tremoli[SUP] 2 [/SUP], Marina Camera[SUP] 1 3 [/SUP]
Affiliations
- PMID: 34384321
- DOI: 10.1080/09537104.2021.1962519
Abstract
Coronavirus disease 2019 (COVID-19) is a pandemic syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection induces a process of inflammation and thrombosis supported by an altered platelet activation state. This platelet activation is peculiar being characterized by the formation of platelet-leukocytes rather than platelet-platelet aggregates and by an increased procoagulant potential supported by elevated levels of TF positive platelets and microvesicles.Therapeutic strategies targeting, beyond systemic inflammation (i.e. with tocilizumab, an anti interleukin-6 receptor), this state of platelet activation might therefore be beneficial. Among the antithrombotic drugs proposed as candidates to treat patients with SARS-CoV-2 infection, antiplatelet drugs, such as aspirin are showing promising results.
Keywords: Antiplatelet drugs; COVID-19; coagulation; platelets; thrombosis.