tetano
Editor, Senior Moderator
Plasmonics
. 2022 Jan 27;1-13.
doi: 10.1007/s11468-021-01589-1. Online ahead of print.
Silicon Nitride-BP-Based Surface Plasmon Resonance Highly Sensitive Biosensor for Virus SARS-CoV-2 Detection
Awadhesh Kumar[SUP] 1 [/SUP], Anil Kumar[SUP] 1 [/SUP], S K Srivastava[SUP] 1 [/SUP]
Affiliations
Abstract
In this study, we propose a surface plasmon resonance (SPR)-based biosensor using silicon nitride (Si[SUB]3[/SUB]N[SUB]4[/SUB]), black phosphorous (BP), and thiol-tethered DNA as a ligand for fast detection of the SARS-CoV-2 virus. In the proposed biosensor, we have deposited silver (Ag), Si[SUB]3[/SUB]N[SUB]4[/SUB], and BP on the base of the BK-7 prism and investigated the performance parameters on the probe in different combinations of the mentioned materials. Herein, three (Ag, Si[SUB]3[/SUB]N[SUB]4[/SUB], and BP) different configurations are introduced and compared for the detection of SARS-CoV-2. Furthermore, with the help of the transfer matrix method (TMM), all the three configurations have been analyzed. Notably, the combination of Ag, Si[SUB]3[/SUB]N[SUB]4[/SUB], and BP shows better sensitivity (154°/RIU) when compared with other configurations for the detection of SARS-CoV-2. This work may facilitate a new sensing device to detect SARS-CoV-2, based on the hybrid materials.
Keywords: Coronavirus disease; Detection accuracy; SARS-CoV-2; Sensitivity; Silicon nitride; Surface plasmon resonance.
. 2022 Jan 27;1-13.
doi: 10.1007/s11468-021-01589-1. Online ahead of print.
Silicon Nitride-BP-Based Surface Plasmon Resonance Highly Sensitive Biosensor for Virus SARS-CoV-2 Detection
Awadhesh Kumar[SUP] 1 [/SUP], Anil Kumar[SUP] 1 [/SUP], S K Srivastava[SUP] 1 [/SUP]
Affiliations
- PMID: 35103050
- PMCID: PMC8791766
- DOI: 10.1007/s11468-021-01589-1
Abstract
In this study, we propose a surface plasmon resonance (SPR)-based biosensor using silicon nitride (Si[SUB]3[/SUB]N[SUB]4[/SUB]), black phosphorous (BP), and thiol-tethered DNA as a ligand for fast detection of the SARS-CoV-2 virus. In the proposed biosensor, we have deposited silver (Ag), Si[SUB]3[/SUB]N[SUB]4[/SUB], and BP on the base of the BK-7 prism and investigated the performance parameters on the probe in different combinations of the mentioned materials. Herein, three (Ag, Si[SUB]3[/SUB]N[SUB]4[/SUB], and BP) different configurations are introduced and compared for the detection of SARS-CoV-2. Furthermore, with the help of the transfer matrix method (TMM), all the three configurations have been analyzed. Notably, the combination of Ag, Si[SUB]3[/SUB]N[SUB]4[/SUB], and BP shows better sensitivity (154°/RIU) when compared with other configurations for the detection of SARS-CoV-2. This work may facilitate a new sensing device to detect SARS-CoV-2, based on the hybrid materials.
Keywords: Coronavirus disease; Detection accuracy; SARS-CoV-2; Sensitivity; Silicon nitride; Surface plasmon resonance.