tetano
Editor, Senior Moderator
Physiol Rep
. 2023 Jan;11(1):e15560.
doi: 10.14814/phy2.15560.
Monthly transthoracic echocardiography in young adults for 6 months following SARS-CoV-2 infection
Sophie S Osada[SUP] 1 [/SUP], Rachel E Szeghy[SUP] 1 [/SUP], Nina L Stute[SUP] 1 [/SUP], Valesha M Province[SUP] 1 [/SUP], Marc A Augenreich[SUP] 1 [/SUP], Andrew Putnam[SUP] 2 [/SUP], Jonathon L Stickford[SUP] 1 [/SUP], Abigail S L Stickford[SUP] 1 [/SUP], Gregory J Grosicki[SUP] 3 [/SUP], Stephen M Ratchford[SUP] 1 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit acute and long-term effects on the myocardium among survivors, yet effects among otherwise healthy young adults remains unclear. Young adults with mild symptoms of SARS-CoV-2 (8M/8F, age: 21 ± 1 years, BMI: 23.5 ± 3.1 kg·m[SUP]-2[/SUP] ) underwent monthly transthoracic echocardiography (TTE) and testing of circulating cardiac troponin-I for months 1-6 (M1-M6) following a positive polymerase chain reaction test to better understand the acute effects and post-acute sequelae of SARS-CoV-2 on cardiac structure and function. Left heart structure and ejection fraction were unaltered from M1-M6 (p > 0.05). While most parameters of septal and lateral wall velocities, mitral and tricuspid valve, and pulmonary vein (PV) were unaltered from M1-M6 (p > 0.05), lateral wall s' wave velocity increased (M1: 0.113 ± 0.019 m·s[SUP]-1[/SUP] , M6: 0.135 ± 0.022 m·s[SUP]-1[/SUP] , p = 0.013); PV S wave velocity increased (M1: 0.596 ± 0.099 m·s[SUP]-1[/SUP] , M6: 0.824 ± 0.118 m·s[SUP]-1[/SUP] , p < 0.001); the difference between PV A wave and mitral valve (MV) A wave durations decreased (M1: 39.139 ± 43.715 ms, M6: 18.037 ± 7.227 ms, p = 0.002); the ratio of PV A duration to MV A duration increased (M1: 0.844 ± 0.205, M6: 1.013 ± 0.132, p = 0.013); and cardiac troponin-I levels decreased (M1: 0.38 ± 0.20 ng·ml[SUP]-1[/SUP] , M3: 0.28 ± 0.34 ng·ml[SUP]-1[/SUP] , M6: 0.29 ± 0.16 ng·ml[SUP]-1[/SUP] ; p = 0.002) over time. While young adults with mild symptoms of SARS-CoV-2 lacked changes to cardiac structure, the subclinical improvements to cardiac function and reduced inflammatory marker of cardiac troponin-I over 6 months following SARS-CoV-2 infection provide physiologic guidance to post-acute sequelae and recovery from SARS-CoV-2 and its variants using conventional TTE.
Keywords: COVID-19; cardiac structure and function; cardiac troponin-I; transthoracic echocardiography.
. 2023 Jan;11(1):e15560.
doi: 10.14814/phy2.15560.
Monthly transthoracic echocardiography in young adults for 6 months following SARS-CoV-2 infection
Sophie S Osada[SUP] 1 [/SUP], Rachel E Szeghy[SUP] 1 [/SUP], Nina L Stute[SUP] 1 [/SUP], Valesha M Province[SUP] 1 [/SUP], Marc A Augenreich[SUP] 1 [/SUP], Andrew Putnam[SUP] 2 [/SUP], Jonathon L Stickford[SUP] 1 [/SUP], Abigail S L Stickford[SUP] 1 [/SUP], Gregory J Grosicki[SUP] 3 [/SUP], Stephen M Ratchford[SUP] 1 [/SUP]
Affiliations
- PMID: 36597212
- DOI: 10.14814/phy2.15560
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit acute and long-term effects on the myocardium among survivors, yet effects among otherwise healthy young adults remains unclear. Young adults with mild symptoms of SARS-CoV-2 (8M/8F, age: 21 ± 1 years, BMI: 23.5 ± 3.1 kg·m[SUP]-2[/SUP] ) underwent monthly transthoracic echocardiography (TTE) and testing of circulating cardiac troponin-I for months 1-6 (M1-M6) following a positive polymerase chain reaction test to better understand the acute effects and post-acute sequelae of SARS-CoV-2 on cardiac structure and function. Left heart structure and ejection fraction were unaltered from M1-M6 (p > 0.05). While most parameters of septal and lateral wall velocities, mitral and tricuspid valve, and pulmonary vein (PV) were unaltered from M1-M6 (p > 0.05), lateral wall s' wave velocity increased (M1: 0.113 ± 0.019 m·s[SUP]-1[/SUP] , M6: 0.135 ± 0.022 m·s[SUP]-1[/SUP] , p = 0.013); PV S wave velocity increased (M1: 0.596 ± 0.099 m·s[SUP]-1[/SUP] , M6: 0.824 ± 0.118 m·s[SUP]-1[/SUP] , p < 0.001); the difference between PV A wave and mitral valve (MV) A wave durations decreased (M1: 39.139 ± 43.715 ms, M6: 18.037 ± 7.227 ms, p = 0.002); the ratio of PV A duration to MV A duration increased (M1: 0.844 ± 0.205, M6: 1.013 ± 0.132, p = 0.013); and cardiac troponin-I levels decreased (M1: 0.38 ± 0.20 ng·ml[SUP]-1[/SUP] , M3: 0.28 ± 0.34 ng·ml[SUP]-1[/SUP] , M6: 0.29 ± 0.16 ng·ml[SUP]-1[/SUP] ; p = 0.002) over time. While young adults with mild symptoms of SARS-CoV-2 lacked changes to cardiac structure, the subclinical improvements to cardiac function and reduced inflammatory marker of cardiac troponin-I over 6 months following SARS-CoV-2 infection provide physiologic guidance to post-acute sequelae and recovery from SARS-CoV-2 and its variants using conventional TTE.
Keywords: COVID-19; cardiac structure and function; cardiac troponin-I; transthoracic echocardiography.