tetano
Editor, Senior Moderator
Vet Microbiol. 2014 Mar 2. pii: S0378-1135(14)00121-7. doi: 10.1016/j.vetmic.2014.02.031. [Epub ahead of print]
Phylogeny of Spanish swine influenza viruses isolated from respiratory disease outbreaks and evolution of swine influenza virus within an endemically infected farm.
Mart?n-Valls GE1, Simon-Grif? M2, van Boheemen S3, de Graaf M4, Bestebroer TM5, Busquets N6, Mart?n M7, Casal J8, Fouchier RA9, Mateu E10.
Author information
Abstract
In the present study, outbreaks of respiratory disease were investigated for the presence of swine influenza virus (SIV). In 14 cases the circulating SIV strains were isolated, fully sequenced and compared with other known SIVs. The viruses causing the outbreaks belonged to the H1N1 (including human pandemic H1N1), H3N2 and H1N2 subtypes. In 11/14 cases the phylogenetic analyses indicated the occurrence of probable reassortment events. In the second part of the study, the genetic evolution of H1N1 SIV was assessed in a longitudinal study in closed groups of pigs over six months. Sequencing of the 22 isolates indicated co-circulation of two different variants for the same virus, as well as the emergence of SIV reassortants at certain time-points. These results indicate that reassortment events in SIV are common, and point towards the need for a better understanding of the epidemiology of SIV, particularly in endemic farms.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Influenza, Reassortment, SIV emergence, Swine
PMID:
24685238
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24685238
Phylogeny of Spanish swine influenza viruses isolated from respiratory disease outbreaks and evolution of swine influenza virus within an endemically infected farm.
Mart?n-Valls GE1, Simon-Grif? M2, van Boheemen S3, de Graaf M4, Bestebroer TM5, Busquets N6, Mart?n M7, Casal J8, Fouchier RA9, Mateu E10.
Author information
Abstract
In the present study, outbreaks of respiratory disease were investigated for the presence of swine influenza virus (SIV). In 14 cases the circulating SIV strains were isolated, fully sequenced and compared with other known SIVs. The viruses causing the outbreaks belonged to the H1N1 (including human pandemic H1N1), H3N2 and H1N2 subtypes. In 11/14 cases the phylogenetic analyses indicated the occurrence of probable reassortment events. In the second part of the study, the genetic evolution of H1N1 SIV was assessed in a longitudinal study in closed groups of pigs over six months. Sequencing of the 22 isolates indicated co-circulation of two different variants for the same virus, as well as the emergence of SIV reassortants at certain time-points. These results indicate that reassortment events in SIV are common, and point towards the need for a better understanding of the epidemiology of SIV, particularly in endemic farms.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Influenza, Reassortment, SIV emergence, Swine
PMID:
24685238
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24685238