tetano
Editor, Senior Moderator
Photodiagnosis Photodyn Ther
. 2022 Feb 15;102762.
doi: 10.1016/j.pdpdt.2022.102762. Online ahead of print.
aPDT for oral decontamination of hospitalized patients with COVID 19
Susana Morimoto[SUP] 1 [/SUP], João Luiz Azevedo Rosin[SUP] 2 [/SUP], Bruno Fernandes Matuck[SUP] 3 [/SUP], Gabriella Schröter[SUP] 4 [/SUP], Maria Fernanda Setúbal Destro Rodrigues[SUP] 5 [/SUP], Karen M Ramalho[SUP] 6 [/SUP], Daniela Procida Raggio[SUP] 7 [/SUP], Maria Stella Moreira[SUP] 8 [/SUP]
Affiliations
Abstract
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants may have an impact on the virus's transmissibility and pathogenicity and an increased risk of reinfection. Antimicrobial photodynamic therapy (aPDT) is a promising technique to decontaminate the oral cavity to minimize and inactivate microorganisms' load. This article reports through a case series, a proposal for efficient oral decontamination for hospitalized patients with COVID 19 using aPDT. Samples of oral tissues were obtained after aPDT and analyzed using two methods of RT-qPCR to elucidate qualitative and quantitative viral profiles of SARS-CoV-2 RNA in the oral cavity. There was a reduction of viral load in the oral cavity immediately or one hour after the use of aPDT. This method could be a good option to decontaminate the oral cavity to minimize and inactivate microorganism load.
Keywords: COVID-19; Photodynamic therapies; SARS-CoV-2; oral decontamination.
. 2022 Feb 15;102762.
doi: 10.1016/j.pdpdt.2022.102762. Online ahead of print.
aPDT for oral decontamination of hospitalized patients with COVID 19
Susana Morimoto[SUP] 1 [/SUP], João Luiz Azevedo Rosin[SUP] 2 [/SUP], Bruno Fernandes Matuck[SUP] 3 [/SUP], Gabriella Schröter[SUP] 4 [/SUP], Maria Fernanda Setúbal Destro Rodrigues[SUP] 5 [/SUP], Karen M Ramalho[SUP] 6 [/SUP], Daniela Procida Raggio[SUP] 7 [/SUP], Maria Stella Moreira[SUP] 8 [/SUP]
Affiliations
- PMID: 35181510
- DOI: 10.1016/j.pdpdt.2022.102762
Abstract
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants may have an impact on the virus's transmissibility and pathogenicity and an increased risk of reinfection. Antimicrobial photodynamic therapy (aPDT) is a promising technique to decontaminate the oral cavity to minimize and inactivate microorganisms' load. This article reports through a case series, a proposal for efficient oral decontamination for hospitalized patients with COVID 19 using aPDT. Samples of oral tissues were obtained after aPDT and analyzed using two methods of RT-qPCR to elucidate qualitative and quantitative viral profiles of SARS-CoV-2 RNA in the oral cavity. There was a reduction of viral load in the oral cavity immediately or one hour after the use of aPDT. This method could be a good option to decontaminate the oral cavity to minimize and inactivate microorganism load.
Keywords: COVID-19; Photodynamic therapies; SARS-CoV-2; oral decontamination.