tetano
Editor, Senior Moderator
ACS Med Chem Lett. 2015 Jan 29;6(3):355-358. eCollection 2015.
[h=1]Phenolic Diterpenoid Derivatives as Anti-Influenza A Virus Agents.[/h] Dang Z[SUP]1[/SUP], Jung K[SUP]1[/SUP], Zhu L[SUP]1[/SUP], Xie H[SUP]2[/SUP], Lee KH[SUP]3[/SUP], Chen CH[SUP]1[/SUP], Huang L[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.
[h=4]KEYWORDS:[/h] Influenza A; hemagglutinin; influenza inhibitor; podocarpic acid; totarol
PMID: 25815159 [PubMed - as supplied by publisher]
[h=1]Phenolic Diterpenoid Derivatives as Anti-Influenza A Virus Agents.[/h] Dang Z[SUP]1[/SUP], Jung K[SUP]1[/SUP], Zhu L[SUP]1[/SUP], Xie H[SUP]2[/SUP], Lee KH[SUP]3[/SUP], Chen CH[SUP]1[/SUP], Huang L[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.
[h=4]KEYWORDS:[/h] Influenza A; hemagglutinin; influenza inhibitor; podocarpic acid; totarol
PMID: 25815159 [PubMed - as supplied by publisher]