tetano
Editor, Senior Moderator
Pharmacol Rep
. 2022 Nov 14.
doi: 10.1007/s43440-022-00433-5. Online ahead of print.
Health-related quality of life in survivors of severe COVID-19 infection
Gabriele d'Ettorre[SUP] 1 [/SUP], Paolo Vassalini[SUP] 2 [/SUP], Vincenzo Coppolelli[SUP] 2 [/SUP], Elio Gentilini Cacciola[SUP] 2 [/SUP], Letizia Sanitinelli[SUP] 2 [/SUP], Luca Maddaloni[SUP] 2 [/SUP], Silvia Fabris[SUP] 3 [/SUP], Claudio M Mastroianni[SUP] 2 [/SUP], Gabriella d'Ettorre[SUP] 2 [/SUP], Giancarlo Ceccarelli[SUP] 4 5 [/SUP]
Affiliations
Abstract
Background: Long-term effects of Coronavirus Disease 2019 (COVID-19) are increasingly recognized as having a significant impact on Health-Related Quality of Life (HRQoL). Understanding HRQoL status for each patient affected by long COVID-19 and its determinants may have a key role to prevent and treat this condition.
Methods: In this prospective observational study conducted in a large academic COVID-19 hospital in Rome, participants were contacted 2 years after hospital admission for severe COVID-19. To assess HRQoL, EQ-5D-5L and Visual analog scale (EQ VAS) standard questionnaires were administered by interview. Logistic regression model was used to the five health dimensions as dependent variables (0 = no problem, 1 = some/extreme problem).
Key results: In 137 enrolled patients, the mean pre-COVID and post-COVID EQ-5D-5L index and EQ-VAS score were 0.97 (SD 0.06), 0.79 (SD 0.26) and 72.38 (SD 15.18), respectively. After subdivision of the participants for clinical and social variables, the EQ-5D-5L index resulted significantly lower than in the pre-COVID-19 period. Female gender, unemployed status, and chronic comorbidities were the most common predictors for having any problems in each EQ-5D-5L domain, while also older age and higher Body Mass Index (BMI) showed to be related to a lower EQ-VAS score.
Conclusion: HRQoL showed to be still low in patients 2 years after acute severe COVID-19. Given the significant impact of SARS-CoV-2 on long-term chronic symptoms, predictors of poor outcomes must be considered during the acute phase of illness to plan a tailored follow-up path for each patient.
Keywords: COVID-19; HRQoL; Health-related quality of life; Post-COVID; Quality of life; SARS-CoV2.
. 2022 Nov 14.
doi: 10.1007/s43440-022-00433-5. Online ahead of print.
Health-related quality of life in survivors of severe COVID-19 infection
Gabriele d'Ettorre[SUP] 1 [/SUP], Paolo Vassalini[SUP] 2 [/SUP], Vincenzo Coppolelli[SUP] 2 [/SUP], Elio Gentilini Cacciola[SUP] 2 [/SUP], Letizia Sanitinelli[SUP] 2 [/SUP], Luca Maddaloni[SUP] 2 [/SUP], Silvia Fabris[SUP] 3 [/SUP], Claudio M Mastroianni[SUP] 2 [/SUP], Gabriella d'Ettorre[SUP] 2 [/SUP], Giancarlo Ceccarelli[SUP] 4 5 [/SUP]
Affiliations
- PMID: 36376776
- DOI: 10.1007/s43440-022-00433-5
Abstract
Background: Long-term effects of Coronavirus Disease 2019 (COVID-19) are increasingly recognized as having a significant impact on Health-Related Quality of Life (HRQoL). Understanding HRQoL status for each patient affected by long COVID-19 and its determinants may have a key role to prevent and treat this condition.
Methods: In this prospective observational study conducted in a large academic COVID-19 hospital in Rome, participants were contacted 2 years after hospital admission for severe COVID-19. To assess HRQoL, EQ-5D-5L and Visual analog scale (EQ VAS) standard questionnaires were administered by interview. Logistic regression model was used to the five health dimensions as dependent variables (0 = no problem, 1 = some/extreme problem).
Key results: In 137 enrolled patients, the mean pre-COVID and post-COVID EQ-5D-5L index and EQ-VAS score were 0.97 (SD 0.06), 0.79 (SD 0.26) and 72.38 (SD 15.18), respectively. After subdivision of the participants for clinical and social variables, the EQ-5D-5L index resulted significantly lower than in the pre-COVID-19 period. Female gender, unemployed status, and chronic comorbidities were the most common predictors for having any problems in each EQ-5D-5L domain, while also older age and higher Body Mass Index (BMI) showed to be related to a lower EQ-VAS score.
Conclusion: HRQoL showed to be still low in patients 2 years after acute severe COVID-19. Given the significant impact of SARS-CoV-2 on long-term chronic symptoms, predictors of poor outcomes must be considered during the acute phase of illness to plan a tailored follow-up path for each patient.
Keywords: COVID-19; HRQoL; Health-related quality of life; Post-COVID; Quality of life; SARS-CoV2.