tetano
Editor, Senior Moderator
Pharmacol Rep
. 2022 Jan 15.
doi: 10.1007/s43440-021-00344-x. Online ahead of print.
A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2
Kasi Pandima Devi[SUP] 1 [/SUP], Mahmoud Reza Pourkarim[SUP] 2 3 [/SUP], Marijn Thijssen[SUP] 4 [/SUP], Antoni Sureda[SUP] 5 6 [/SUP], Maryam Khayatkashani[SUP] 7 [/SUP], Cosmin Andrei Cismaru[SUP] 8 9 [/SUP], Ioana Berindan Neagoe[SUP] 8 10 11 [/SUP], Solomon Habtemariam[SUP] 12 [/SUP], Soha Razmjouei[SUP] 13 [/SUP], Hamid Reza Khayat Kashani[SUP] 14 [/SUP]
Affiliations
Abstract
Currently, the world is facing a pandemic of the new coronavirus SARS-CoV-2 that causes COVID-19. Identifying key targets in the viral infection lifecycle is urgently needed for designing therapeutic strategies to combat the virus. Furin is a subtilisin-like proprotein convertase with diverse cellular functions. Emerging evidence suggests that furin plays a critical role in the activation and/or infectivity of SARS-CoV-2. In this perspective, we discuss the potential role of furin in the entry SARS-CoV-2 into host cells. Furthermore, we evaluate available peptide and non-peptide furin inhibitors and potential outcomes, including immune responses.
Keywords: Furin inhibitor; Immune responses; Non-peptide; Peptide; SARS-CoV-2; Spike protein.
. 2022 Jan 15.
doi: 10.1007/s43440-021-00344-x. Online ahead of print.
A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2
Kasi Pandima Devi[SUP] 1 [/SUP], Mahmoud Reza Pourkarim[SUP] 2 3 [/SUP], Marijn Thijssen[SUP] 4 [/SUP], Antoni Sureda[SUP] 5 6 [/SUP], Maryam Khayatkashani[SUP] 7 [/SUP], Cosmin Andrei Cismaru[SUP] 8 9 [/SUP], Ioana Berindan Neagoe[SUP] 8 10 11 [/SUP], Solomon Habtemariam[SUP] 12 [/SUP], Soha Razmjouei[SUP] 13 [/SUP], Hamid Reza Khayat Kashani[SUP] 14 [/SUP]
Affiliations
- PMID: 35031970
- DOI: 10.1007/s43440-021-00344-x
Abstract
Currently, the world is facing a pandemic of the new coronavirus SARS-CoV-2 that causes COVID-19. Identifying key targets in the viral infection lifecycle is urgently needed for designing therapeutic strategies to combat the virus. Furin is a subtilisin-like proprotein convertase with diverse cellular functions. Emerging evidence suggests that furin plays a critical role in the activation and/or infectivity of SARS-CoV-2. In this perspective, we discuss the potential role of furin in the entry SARS-CoV-2 into host cells. Furthermore, we evaluate available peptide and non-peptide furin inhibitors and potential outcomes, including immune responses.
Keywords: Furin inhibitor; Immune responses; Non-peptide; Peptide; SARS-CoV-2; Spike protein.