tetano
Editor, Senior Moderator
Intern Med. 2016;55(13):1807-10. doi: 10.2169/internalmedicine.55.6327. Epub 2016 Jul 1.
[h=1]Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma.[/h] Kawakami T[SUP]1[/SUP], Hirabayashi Y, Kawakami F, Isobe R, Kaneko N, Mimura Y, Ito T, Furuta K, Shimazaki M, Nakazawa H, Kitano K.
[h=3]Author information[/h]
[h=3]Abstract[/h] We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. These findings suggest that a drug-resistant influenza virus strain might selectively survive antiviral therapy in elderly patients with refractory malignant lymphoma undergoing multiple chemotherapies.
PMID: 27374689 DOI: 10.2169/internalmedicine.55.6327
[PubMed - in process]
[h=1]Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma.[/h] Kawakami T[SUP]1[/SUP], Hirabayashi Y, Kawakami F, Isobe R, Kaneko N, Mimura Y, Ito T, Furuta K, Shimazaki M, Nakazawa H, Kitano K.
[h=3]Author information[/h]
[h=3]Abstract[/h] We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. These findings suggest that a drug-resistant influenza virus strain might selectively survive antiviral therapy in elderly patients with refractory malignant lymphoma undergoing multiple chemotherapies.
PMID: 27374689 DOI: 10.2169/internalmedicine.55.6327
[PubMed - in process]