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Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents

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Editor, Senior Moderator
Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents

G?nter Kampf[SUP]1[/SUP][SUP],[/SUP][SUP]∗[/SUP][SUP],[/SUP]Correspondence information about the author G?nter KampfEmail the author G?nter Kampf
,
Daniel Todt[SUP]2[/SUP]
,
Stephanie Pfaender[SUP]2[/SUP]
,
Eike Steinmann[SUP]2[/SUP]

PlumX Metrics
DOI: https://doi.org/10.1016/j.jhin.2020.01.022 Article Info
Article Outline
  1. Introduction
  2. Method
  3. Results
    1. Persistence of coronavirus on inanimate surfaces
    2. Inactivation of coronaviruses by biocidal agents in suspension tests
    3. Inactivation of coronaviruses by biocidal agents in carrier tests
  4. Discussion
  5. Conclusions
  6. Declaration of Competing Interest
  7. References
Summary


Currently, the emergence of a novel human coronavirus, temporary named 2019-nCoV, has become a global health concern causing severe respiratory tract infections in humans. Human-to-human transmissions have been described with incubation times between 2-10 days, facilitating its spread via droplets, contaminated hands or surfaces. We therefore reviewed the literature on all available information about the persistence of human and veterinary coronaviruses on inanimate surfaces as well as inactivation strategies with biocidal agents used for chemical disinfection, e.g. in healthcare facilities. The analysis of 22 studies reveals that human coronaviruses such as Severe Acute Respiratory Syndrome (SARS) coronavirus, Middle East Respiratory Syndrome (MERS) coronavirus or endemic human coronaviruses (HCoV) can persist on inanimate surfaces like metal, glass or plastic for up to 9 days, but can be efficiently inactivated by surface disinfection procedures with 62-71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite within 1 minute. Other biocidal agents such as 0.05-0.2% benzalkonium chloride or 0.02% chlorhexidine digluconate are less effective. As no specific therapies are available for 2019-nCoV, early containment and prevention of further spread will be crucial to stop the ongoing outbreak and to control this novel infectious thread.

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https://www.journalofhospitalinfecti...046-3/fulltext
 
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