tetano
Editor, Senior Moderator
Vaccine. 2018 Jun 16. pii: S0264-410X(18)30823-5. doi: 10.1016/j.vaccine.2018.05.125. [Epub ahead of print]
[h=1]Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication.[/h] Dai X[SUP]1[/SUP], Li N[SUP]2[/SUP], Roller RJ[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Cellular proteins that support influenza virus infection represent potential therapeutic targets. Cytoplasmic egress intermediates of influenza A/WSN/33 were isolated and shown to be associated with the cellular enzymes peroxiredoxins-1 (Prdx-1) during glycerol gradient fractionation. Prdx-1 also co-localizes with influenza NP at the cell periphery late in infection. Knock-down or knockout of Prdx-1 expression inhibit influenza A replication. Inhibition of replication is not correlated with defects in initiation of infection or mRNA expression, but is correlated with inhibition of accumulation of viral proteins and vRNAs.
[h=4]KEYWORDS:[/h] Influenza; Peroxiredoxin-1; Ribonucleoprotein
PMID: 29921490 DOI: 10.1016/j.vaccine.2018.05.125
[h=1]Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication.[/h] Dai X[SUP]1[/SUP], Li N[SUP]2[/SUP], Roller RJ[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Cellular proteins that support influenza virus infection represent potential therapeutic targets. Cytoplasmic egress intermediates of influenza A/WSN/33 were isolated and shown to be associated with the cellular enzymes peroxiredoxins-1 (Prdx-1) during glycerol gradient fractionation. Prdx-1 also co-localizes with influenza NP at the cell periphery late in infection. Knock-down or knockout of Prdx-1 expression inhibit influenza A replication. Inhibition of replication is not correlated with defects in initiation of infection or mRNA expression, but is correlated with inhibition of accumulation of viral proteins and vRNAs.
[h=4]KEYWORDS:[/h] Influenza; Peroxiredoxin-1; Ribonucleoprotein
PMID: 29921490 DOI: 10.1016/j.vaccine.2018.05.125