tetano
Editor, Senior Moderator
Pediatrics. 2016 Jan 5. pii: peds.2015-3279. [Epub ahead of print]
[h=1]Seasonal Effectiveness of Live Attenuated and Inactivated Influenza Vaccine.[/h] Chung JR[SUP]1[/SUP], Flannery B[SUP]2[/SUP], Thompson MG[SUP]2[/SUP], Gaglani M[SUP]3[/SUP], Jackson ML[SUP]4[/SUP], Monto AS[SUP]5[/SUP], Nowalk MP[SUP]6[/SUP], Talbot HK[SUP]7[/SUP], Treanor JJ[SUP]8[/SUP], Belongia EA[SUP]9[/SUP], Murthy K[SUP]3[/SUP], Jackson LA[SUP]4[/SUP], Petrie JG[SUP]5[/SUP], Zimmerman RK[SUP]6[/SUP], Griffin MR[SUP]7[/SUP], McLean HQ[SUP]9[/SUP], Fry AM[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Few observational studies have evaluated the relative effectiveness of live attenuated (LAIV) and inactivated (IIV) influenza vaccines against medically attended laboratory-confirmed influenza.
[h=4]METHODS:[/h] We analyzed US Influenza Vaccine Effectiveness Network data from participants aged 2 to 17 years during 4 seasons (2010-2011 through 2013-2014) to compare relative effectiveness of LAIV and IIV against influenza-associated illness. Vaccine receipt was confirmed via provider/electronic medical records or immunization registry. We calculated the ratio (odds) of influenza-positive to influenza-negative participants among those age-appropriately vaccinated with either LAIV or IIV for the corresponding season. We examined relative effectiveness of LAIV and IIV by using adjusted odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression.
[h=4]RESULTS:[/h] Of 6819 participants aged 2 to 17 years, 2703 were age-appropriately vaccinated with LAIV (n = 637) or IIV (n = 2066). Odds of influenza were similar for LAIV and IIV recipients during 3 seasons (2010-2011 through 2012-2013). In 2013-2014, odds of influenza were significantly higher among LAIV recipients compared with IIV recipients 2 to 8 years old (OR 5.36; 95% CI, 2.37 to 12.13). Participants vaccinated with LAIV or IIV had similar odds of illness associated with influenza A/H3N2 or B. LAIV recipients had greater odds of illness due to influenza A/H1N1pdm09 in 2010-2011 and 2013-2014.
[h=4]CONCLUSIONS:[/h] We observed lower effectiveness of LAIV compared with IIV against influenza A/H1N1pdm09 but not A(H3N2) or B among children and adolescents, suggesting poor performance related to the LAIV A/H1N1pdm09 viral construct.
Copyright ? 2016 by the American Academy of Pediatrics.
PMID: 26738884 [PubMed - as supplied by publisher]
[h=1]Seasonal Effectiveness of Live Attenuated and Inactivated Influenza Vaccine.[/h] Chung JR[SUP]1[/SUP], Flannery B[SUP]2[/SUP], Thompson MG[SUP]2[/SUP], Gaglani M[SUP]3[/SUP], Jackson ML[SUP]4[/SUP], Monto AS[SUP]5[/SUP], Nowalk MP[SUP]6[/SUP], Talbot HK[SUP]7[/SUP], Treanor JJ[SUP]8[/SUP], Belongia EA[SUP]9[/SUP], Murthy K[SUP]3[/SUP], Jackson LA[SUP]4[/SUP], Petrie JG[SUP]5[/SUP], Zimmerman RK[SUP]6[/SUP], Griffin MR[SUP]7[/SUP], McLean HQ[SUP]9[/SUP], Fry AM[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Few observational studies have evaluated the relative effectiveness of live attenuated (LAIV) and inactivated (IIV) influenza vaccines against medically attended laboratory-confirmed influenza.
[h=4]METHODS:[/h] We analyzed US Influenza Vaccine Effectiveness Network data from participants aged 2 to 17 years during 4 seasons (2010-2011 through 2013-2014) to compare relative effectiveness of LAIV and IIV against influenza-associated illness. Vaccine receipt was confirmed via provider/electronic medical records or immunization registry. We calculated the ratio (odds) of influenza-positive to influenza-negative participants among those age-appropriately vaccinated with either LAIV or IIV for the corresponding season. We examined relative effectiveness of LAIV and IIV by using adjusted odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression.
[h=4]RESULTS:[/h] Of 6819 participants aged 2 to 17 years, 2703 were age-appropriately vaccinated with LAIV (n = 637) or IIV (n = 2066). Odds of influenza were similar for LAIV and IIV recipients during 3 seasons (2010-2011 through 2012-2013). In 2013-2014, odds of influenza were significantly higher among LAIV recipients compared with IIV recipients 2 to 8 years old (OR 5.36; 95% CI, 2.37 to 12.13). Participants vaccinated with LAIV or IIV had similar odds of illness associated with influenza A/H3N2 or B. LAIV recipients had greater odds of illness due to influenza A/H1N1pdm09 in 2010-2011 and 2013-2014.
[h=4]CONCLUSIONS:[/h] We observed lower effectiveness of LAIV compared with IIV against influenza A/H1N1pdm09 but not A(H3N2) or B among children and adolescents, suggesting poor performance related to the LAIV A/H1N1pdm09 viral construct.
Copyright ? 2016 by the American Academy of Pediatrics.
PMID: 26738884 [PubMed - as supplied by publisher]