tetano
Editor, Senior Moderator
Pediatrics
. 2022 Apr 15.
doi: 10.1542/peds.2021-054557. Online ahead of print.
Possible In-Utero Transmission of SARS-CoV-2 and Severe Respiratory Disease in a Preterm Infant
Paul Fleming[SUP] 1 2 [/SUP], Sujith Pereira[SUP] 1 2 [/SUP], Olga Kapellou[SUP] 1 [/SUP], Alleyna Claxton[SUP] 3 [/SUP], Alasdair Bamford[SUP] 4 5 [/SUP], Narendra Aladangady[SUP] 1 2 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are uncommon in newborn infants. This report describes possible in-utero transmission of the B.1.1.7 (Alpha) variant in a preterm infant born at 31 weeks' gestational age who presented with severe respiratory disease. The infant was treated with high frequency oscillatory ventilation, antiviral medications and corticosteroids and transitioned to non-invasive respiratory support on day 33. By day 63, she was off positive pressure support and breathing room air and she was discharged home on day 70. She demonstrated normal growth and development at a 6-month follow-up visit. Placental histopathology revealed placentitis characterised by loss of intervillous spaces due to fibrin deposition and inflammatory cell infiltration. Optimum management strategies for treating infants with severe respiratory SARS-CoV-2 infection have yet to be determined.
. 2022 Apr 15.
doi: 10.1542/peds.2021-054557. Online ahead of print.
Possible In-Utero Transmission of SARS-CoV-2 and Severe Respiratory Disease in a Preterm Infant
Paul Fleming[SUP] 1 2 [/SUP], Sujith Pereira[SUP] 1 2 [/SUP], Olga Kapellou[SUP] 1 [/SUP], Alleyna Claxton[SUP] 3 [/SUP], Alasdair Bamford[SUP] 4 5 [/SUP], Narendra Aladangady[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35425990
- DOI: 10.1542/peds.2021-054557
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are uncommon in newborn infants. This report describes possible in-utero transmission of the B.1.1.7 (Alpha) variant in a preterm infant born at 31 weeks' gestational age who presented with severe respiratory disease. The infant was treated with high frequency oscillatory ventilation, antiviral medications and corticosteroids and transitioned to non-invasive respiratory support on day 33. By day 63, she was off positive pressure support and breathing room air and she was discharged home on day 70. She demonstrated normal growth and development at a 6-month follow-up visit. Placental histopathology revealed placentitis characterised by loss of intervillous spaces due to fibrin deposition and inflammatory cell infiltration. Optimum management strategies for treating infants with severe respiratory SARS-CoV-2 infection have yet to be determined.