tetano
Editor, Senior Moderator
Pediatrics
. 2022 Oct 26;e2022056206.
doi: 10.1542/peds.2022-056206. Online ahead of print.
Infants Born Following SARS-CoV-2 Infection in Pregnancy
Maria Grazia Capretti[SUP] 1 [/SUP], Concetta Marsico[SUP] 1 2 [/SUP], Liliana Gabrielli[SUP] 3 [/SUP], Caterina Vocale[SUP] 4 [/SUP], Santo Arcuri[SUP] 1 2 [/SUP], Giuliana Simonazzi[SUP] 3 5 2 [/SUP], Anna Rita Piccinini[SUP] 6 [/SUP], Cristina Brandolini[SUP] 7 [/SUP], Tiziana Lazzarotto[SUP] 3 8 [/SUP], Luigi Tommaso Corvaglia[SUP] 1 2 [/SUP]
Affiliations
Abstract
Objectives: To evaluate outcomes of neonates born to mothers with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy, the dynamics of placental transfer of maternal antibodies, and its persistence during infancy.
Methods: Cohort study enrolling neonates born to mothers with SARS-CoV-2 infection in pregnancy. All infants were evaluated at birth. Those born to women with infection onset within 2 weeks before delivery were excluded from further analyses. Remaining infants underwent cerebral and abdominal ultrasound, fundoscopy evaluation, and were enrolled in a 12 month follow-up. Qualitative immunoglobulin G (IgG)/immunoglobulin M and quantitative IgG to S1/S2 subunits of spike protein were assessed in mother-neonate dyads within 48 hours postdelivery and during follow-up.
Results: Between April 2020 and April 2021, 130 of 2745 (4.7%) neonates were born to mothers with SARS-CoV-2 infection in pregnancy, with 106 of 130 infections diagnosed before 2 weeks before delivery. Rates of preterm and cesarean delivery were comparable between women with and without infection (6% vs 8%, P = .57; 22% vs 32%, P = .06). No clinical or instrumental abnormalities were detected at birth or during follow-up. There was a positive correlation between maternal and neonatal SARS-CoV-2 IgG levels (r = 0.81, P < .001). Transplacental transfer ratio was higher after second-trimester maternal infections as compared with first and third trimester (P = .03). SARS-CoV-2 IgG level progressively decreased in all infants, with 89 of 92 (97%) infants seronegative at 6 months of age.
Conclusions: Clinical outcomes were favorable in all infants. Matching peak IgG level after infection and higher IgG transplacental transfer might result in the most durable neonatal passive immunity.
. 2022 Oct 26;e2022056206.
doi: 10.1542/peds.2022-056206. Online ahead of print.
Infants Born Following SARS-CoV-2 Infection in Pregnancy
Maria Grazia Capretti[SUP] 1 [/SUP], Concetta Marsico[SUP] 1 2 [/SUP], Liliana Gabrielli[SUP] 3 [/SUP], Caterina Vocale[SUP] 4 [/SUP], Santo Arcuri[SUP] 1 2 [/SUP], Giuliana Simonazzi[SUP] 3 5 2 [/SUP], Anna Rita Piccinini[SUP] 6 [/SUP], Cristina Brandolini[SUP] 7 [/SUP], Tiziana Lazzarotto[SUP] 3 8 [/SUP], Luigi Tommaso Corvaglia[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36285569
- DOI: 10.1542/peds.2022-056206
Abstract
Objectives: To evaluate outcomes of neonates born to mothers with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy, the dynamics of placental transfer of maternal antibodies, and its persistence during infancy.
Methods: Cohort study enrolling neonates born to mothers with SARS-CoV-2 infection in pregnancy. All infants were evaluated at birth. Those born to women with infection onset within 2 weeks before delivery were excluded from further analyses. Remaining infants underwent cerebral and abdominal ultrasound, fundoscopy evaluation, and were enrolled in a 12 month follow-up. Qualitative immunoglobulin G (IgG)/immunoglobulin M and quantitative IgG to S1/S2 subunits of spike protein were assessed in mother-neonate dyads within 48 hours postdelivery and during follow-up.
Results: Between April 2020 and April 2021, 130 of 2745 (4.7%) neonates were born to mothers with SARS-CoV-2 infection in pregnancy, with 106 of 130 infections diagnosed before 2 weeks before delivery. Rates of preterm and cesarean delivery were comparable between women with and without infection (6% vs 8%, P = .57; 22% vs 32%, P = .06). No clinical or instrumental abnormalities were detected at birth or during follow-up. There was a positive correlation between maternal and neonatal SARS-CoV-2 IgG levels (r = 0.81, P < .001). Transplacental transfer ratio was higher after second-trimester maternal infections as compared with first and third trimester (P = .03). SARS-CoV-2 IgG level progressively decreased in all infants, with 89 of 92 (97%) infants seronegative at 6 months of age.
Conclusions: Clinical outcomes were favorable in all infants. Matching peak IgG level after infection and higher IgG transplacental transfer might result in the most durable neonatal passive immunity.