tetano
Editor, Senior Moderator
Pediatr Res
. 2023 Jan 3.
doi: 10.1038/s41390-022-02421-0. Online ahead of print.
Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy
Dingning Zhang[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Tingting Huang[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Zhihui Chen[SUP] 1 2 3 [/SUP], Lulu Zhang[SUP] 1 2 3 [/SUP], Qi Gao[SUP] 1 2 3 [/SUP], Ge Liu[SUP] 1 2 3 [/SUP], Jun Zheng[SUP] 4 5 6 [/SUP], Fangrui Ding[SUP] 7 8 9 [/SUP]
Affiliations
Abstract
Background: The safety of coronavirus disease 2019 (COVID-19) vaccines during pregnancy is a particular concern. Here, we addressed the neonatal outcomes after maternal vaccination of COVID-19 during pregnancy.
Methods: We systematically searched PubMed, EMBASE, and the WHO COVID-19 Database for studies on neonatal outcomes after maternal COVID-19 vaccination from inception to 3 July 2022. Main neonatal outcomes were related to preterm, small for gestation (SGA), NICU admission, low Apgar score at 5 min (<7), and additional neonatal outcomes such as gestation <34 weeks, low birth weight and some neonatal morbidity were all also analyzed.
Results: A total of 15 studies were included. We found that maternal vaccination during pregnancy was related to the reduction rates of Preterm, SGA, Low Apgar score at 5 min (<7). In addition, there was no evidence of a higher risk of adverse neonatal outcomes after maternal vaccination of COVID-19 during pregnancy, including NICU admission, preterm birth with gestation <34 weeks, low birth weight, very low birth weight, congenital anomalies, and so on.
Conclusions: COVID-19 vaccination in pregnant women does not raise significant adverse effects on neonatal outcomes and is related to a protective effect on some neonatal outcomes.
Impact: Present study has addressed the neonatal outcomes after maternal vaccination of COVID-19 during pregnancy. COVID-19 vaccination in pregnant women does not raise significant adverse effects on neonatal outcomes and is related to a protective effect on some neonatal outcomes. The present study could encourage pregnant women to be vaccinated against COVID-19.
. 2023 Jan 3.
doi: 10.1038/s41390-022-02421-0. Online ahead of print.
Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy
Dingning Zhang[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Tingting Huang[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Zhihui Chen[SUP] 1 2 3 [/SUP], Lulu Zhang[SUP] 1 2 3 [/SUP], Qi Gao[SUP] 1 2 3 [/SUP], Ge Liu[SUP] 1 2 3 [/SUP], Jun Zheng[SUP] 4 5 6 [/SUP], Fangrui Ding[SUP] 7 8 9 [/SUP]
Affiliations
- PMID: 36596943
- DOI: 10.1038/s41390-022-02421-0
Abstract
Background: The safety of coronavirus disease 2019 (COVID-19) vaccines during pregnancy is a particular concern. Here, we addressed the neonatal outcomes after maternal vaccination of COVID-19 during pregnancy.
Methods: We systematically searched PubMed, EMBASE, and the WHO COVID-19 Database for studies on neonatal outcomes after maternal COVID-19 vaccination from inception to 3 July 2022. Main neonatal outcomes were related to preterm, small for gestation (SGA), NICU admission, low Apgar score at 5 min (<7), and additional neonatal outcomes such as gestation <34 weeks, low birth weight and some neonatal morbidity were all also analyzed.
Results: A total of 15 studies were included. We found that maternal vaccination during pregnancy was related to the reduction rates of Preterm, SGA, Low Apgar score at 5 min (<7). In addition, there was no evidence of a higher risk of adverse neonatal outcomes after maternal vaccination of COVID-19 during pregnancy, including NICU admission, preterm birth with gestation <34 weeks, low birth weight, very low birth weight, congenital anomalies, and so on.
Conclusions: COVID-19 vaccination in pregnant women does not raise significant adverse effects on neonatal outcomes and is related to a protective effect on some neonatal outcomes.
Impact: Present study has addressed the neonatal outcomes after maternal vaccination of COVID-19 during pregnancy. COVID-19 vaccination in pregnant women does not raise significant adverse effects on neonatal outcomes and is related to a protective effect on some neonatal outcomes. The present study could encourage pregnant women to be vaccinated against COVID-19.