tetano
Editor, Senior Moderator
Pediatr Res
. 2025 Nov 11.
doi: 10.1038/s41390-025-04564-2. Online ahead of print. Neurological and neurodevelopmental effects of Covid and MIS-C on children
D Byrne[SUP] 1 2 3 [/SUP], C Gale[SUP] 4 5 [/SUP], N Canty[SUP] 2 [/SUP], J Meehan[SUP] 3 [/SUP], D Dumitriu[SUP] 6 [/SUP], A Yonts[SUP] 7 [/SUP], S B Mulkey[SUP] 8 9 10 [/SUP], E J Molloy[SUP] 11 12 13 14 15 16 [/SUP]
Affiliations
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been shown to cause a unique disease phenotype in the paediatric population compared to adults, following the emergence of Multisystem Inflammatory Syndrome of Children (MIS-C) and Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS). Over the course of the pandemic, neurological symptoms associated with SARS-CoV-2 have been reported in the paediatric population. The neurological and neurodevelopmental sequelae of both acute SARS-CoV-2 infection and MIS-C/PIMS-TS in the paediatric population are not well understood. Little is known about the underlying pathophysiology and the potential neurovirulence of SARS-CoV-2. Further awareness and research are needed on the neurological sequelae and long-term consequences of SARS-CoV-2 on the developing brain. IMPACT: Detailed review of the current knowledge on neurological and neurodevelopmental effects of SARS-CoV-2 and MIS-C on the paediatric population. Emphasise the importance of acknowledging the potential direct effects of SARS-CoV-2 and MIS-C on neurological and neurodevelopmental outcomes. Highlight the need for further research and inclusion of paediatric patients in follow up studies of long-term effects of SARS-CoV-2 and MIS-C focusing on neurodevelopmental and neurological sequelae.
. 2025 Nov 11.
doi: 10.1038/s41390-025-04564-2. Online ahead of print. Neurological and neurodevelopmental effects of Covid and MIS-C on children
D Byrne[SUP] 1 2 3 [/SUP], C Gale[SUP] 4 5 [/SUP], N Canty[SUP] 2 [/SUP], J Meehan[SUP] 3 [/SUP], D Dumitriu[SUP] 6 [/SUP], A Yonts[SUP] 7 [/SUP], S B Mulkey[SUP] 8 9 10 [/SUP], E J Molloy[SUP] 11 12 13 14 15 16 [/SUP]
Affiliations
- PMID: 41219464
- DOI: 10.1038/s41390-025-04564-2
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been shown to cause a unique disease phenotype in the paediatric population compared to adults, following the emergence of Multisystem Inflammatory Syndrome of Children (MIS-C) and Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS). Over the course of the pandemic, neurological symptoms associated with SARS-CoV-2 have been reported in the paediatric population. The neurological and neurodevelopmental sequelae of both acute SARS-CoV-2 infection and MIS-C/PIMS-TS in the paediatric population are not well understood. Little is known about the underlying pathophysiology and the potential neurovirulence of SARS-CoV-2. Further awareness and research are needed on the neurological sequelae and long-term consequences of SARS-CoV-2 on the developing brain. IMPACT: Detailed review of the current knowledge on neurological and neurodevelopmental effects of SARS-CoV-2 and MIS-C on the paediatric population. Emphasise the importance of acknowledging the potential direct effects of SARS-CoV-2 and MIS-C on neurological and neurodevelopmental outcomes. Highlight the need for further research and inclusion of paediatric patients in follow up studies of long-term effects of SARS-CoV-2 and MIS-C focusing on neurodevelopmental and neurological sequelae.