tetano
Editor, Senior Moderator
Pediatr Obes
. 2022 Oct 12;e12980.
doi: 10.1111/ijpo.12980. Online ahead of print.
Short-term complications and post-acute sequelae in hospitalized paediatric patients with COVID-19 and obesity: A multicenter cohort study
Gonzalo Valenzuela[SUP] 1 2 [/SUP], Gonzalo Alarcón-Andrade[SUP] 1 [/SUP], Clara Schulze-Schiapacasse[SUP] 1 [/SUP], Rocío Rodríguez[SUP] 3 [/SUP], Tamara García-Salum[SUP] 1 2 [/SUP], Catalina Pardo-Roa[SUP] 1 2 [/SUP], Jorge Levican[SUP] 1 [/SUP], Eileen Serrano[SUP] 1 [/SUP], María José Avendaño[SUP] 1 [/SUP], Monserrat Gutiérrez[SUP] 4 5 [/SUP], Loreto Godoy[SUP] 4 5 [/SUP], Pamela Céspedes[SUP] 5 [/SUP], Sandra Bermudez[SUP] 5 [/SUP], Javiera Aravena[SUP] 4 6 [/SUP], Irini Nicolaides[SUP] 4 6 [/SUP], Eliana Martínez[SUP] 4 [/SUP], Constanza Gómez-Canobbio[SUP] 4 [/SUP], Macarena Jofré[SUP] 4 [/SUP], Andrea Salinas[SUP] 4 [/SUP], Daniela Depaoli[SUP] 6 [/SUP], Carolina Loza[SUP] 4 6 [/SUP], Andrés Muñoz[SUP] 4 6 [/SUP], Natalia Ormazábal[SUP] 6 [/SUP], Diana Manzur[SUP] 3 [/SUP], José Barriga[SUP] 3 [/SUP], Leonardo I Almonacid[SUP] 1 [/SUP], Estefany Poblete-Cárdenas[SUP] 1 [/SUP], Erick Salinas[SUP] 1 2 [/SUP], Andrés Muñoz-Marcos[SUP] 1 [/SUP], Salesa Barja[SUP] 4 7 8 [/SUP], Rafael A Medina[SUP] 1 2 9 [/SUP]
Affiliations
Abstract
Background: Obesity increases the severity of coronavirus disease 2019 illness in adults. The role of obesity in short-term complications and post-acute sequelae in children is not well defined.
Objective: To evaluate the relationship between obesity and short-term complications and post-acute sequelae of SARS-CoV-2 infection in hospitalized paediatric patients.
Methods: An observational study was conducted in three tertiary hospitals, including paediatric hospitalized patients with a confirmatory SARS-CoV-2 RT-PCR from March 2020 to December 2021. Obesity was defined according to WHO 2006 (0-2 years) and CDC 2000 (2-20 years) growth references. Short-term outcomes were intensive care unit admission, ventilatory support, superinfections, acute kidney injury, and mortality. Neurological, respiratory, and cardiological symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms were considered as post-acute sequalae. Adjusted linear, logistic regression and generalized estimating equations models were performed.
Results: A total of 216 individuals were included, and 67 (31.02%) of them had obesity. Obesity was associated with intensive care unit admission (aOR = 5.63, CI95% 2.90-10.94), oxygen requirement (aOR = 2.77, CI95% 1.36-5.63), non-invasive ventilatory support (aOR = 6.81, CI95% 2.11-22.04), overall superinfections (aOR = 3.02 CI95% 1.45-6.31), and suspected bacterial pneumonia (aOR = 3.00 CI95% 1.44-6.23). For post-acute sequalae, obesity was associated with dyspnea (aOR = 9.91 CI95% 1.92-51.10) and muscle weakness (aOR = 20.04 CI95% 2.50-160.65).
Conclusions: In paediatric hospitalized patients with COVID-19, severe short-term outcomes and post-acute sequelae are associated with obesity. Recognizing obesity as a key comorbidity is essential to develop targeted strategies for prevention of COVID-19 complications in children.
Keywords: COVID-19; adolescent; child; intensive care units; obesity; post-acute COVID-19 syndrome.
. 2022 Oct 12;e12980.
doi: 10.1111/ijpo.12980. Online ahead of print.
Short-term complications and post-acute sequelae in hospitalized paediatric patients with COVID-19 and obesity: A multicenter cohort study
Gonzalo Valenzuela[SUP] 1 2 [/SUP], Gonzalo Alarcón-Andrade[SUP] 1 [/SUP], Clara Schulze-Schiapacasse[SUP] 1 [/SUP], Rocío Rodríguez[SUP] 3 [/SUP], Tamara García-Salum[SUP] 1 2 [/SUP], Catalina Pardo-Roa[SUP] 1 2 [/SUP], Jorge Levican[SUP] 1 [/SUP], Eileen Serrano[SUP] 1 [/SUP], María José Avendaño[SUP] 1 [/SUP], Monserrat Gutiérrez[SUP] 4 5 [/SUP], Loreto Godoy[SUP] 4 5 [/SUP], Pamela Céspedes[SUP] 5 [/SUP], Sandra Bermudez[SUP] 5 [/SUP], Javiera Aravena[SUP] 4 6 [/SUP], Irini Nicolaides[SUP] 4 6 [/SUP], Eliana Martínez[SUP] 4 [/SUP], Constanza Gómez-Canobbio[SUP] 4 [/SUP], Macarena Jofré[SUP] 4 [/SUP], Andrea Salinas[SUP] 4 [/SUP], Daniela Depaoli[SUP] 6 [/SUP], Carolina Loza[SUP] 4 6 [/SUP], Andrés Muñoz[SUP] 4 6 [/SUP], Natalia Ormazábal[SUP] 6 [/SUP], Diana Manzur[SUP] 3 [/SUP], José Barriga[SUP] 3 [/SUP], Leonardo I Almonacid[SUP] 1 [/SUP], Estefany Poblete-Cárdenas[SUP] 1 [/SUP], Erick Salinas[SUP] 1 2 [/SUP], Andrés Muñoz-Marcos[SUP] 1 [/SUP], Salesa Barja[SUP] 4 7 8 [/SUP], Rafael A Medina[SUP] 1 2 9 [/SUP]
Affiliations
- PMID: 36222077
- DOI: 10.1111/ijpo.12980
Abstract
Background: Obesity increases the severity of coronavirus disease 2019 illness in adults. The role of obesity in short-term complications and post-acute sequelae in children is not well defined.
Objective: To evaluate the relationship between obesity and short-term complications and post-acute sequelae of SARS-CoV-2 infection in hospitalized paediatric patients.
Methods: An observational study was conducted in three tertiary hospitals, including paediatric hospitalized patients with a confirmatory SARS-CoV-2 RT-PCR from March 2020 to December 2021. Obesity was defined according to WHO 2006 (0-2 years) and CDC 2000 (2-20 years) growth references. Short-term outcomes were intensive care unit admission, ventilatory support, superinfections, acute kidney injury, and mortality. Neurological, respiratory, and cardiological symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms were considered as post-acute sequalae. Adjusted linear, logistic regression and generalized estimating equations models were performed.
Results: A total of 216 individuals were included, and 67 (31.02%) of them had obesity. Obesity was associated with intensive care unit admission (aOR = 5.63, CI95% 2.90-10.94), oxygen requirement (aOR = 2.77, CI95% 1.36-5.63), non-invasive ventilatory support (aOR = 6.81, CI95% 2.11-22.04), overall superinfections (aOR = 3.02 CI95% 1.45-6.31), and suspected bacterial pneumonia (aOR = 3.00 CI95% 1.44-6.23). For post-acute sequalae, obesity was associated with dyspnea (aOR = 9.91 CI95% 1.92-51.10) and muscle weakness (aOR = 20.04 CI95% 2.50-160.65).
Conclusions: In paediatric hospitalized patients with COVID-19, severe short-term outcomes and post-acute sequelae are associated with obesity. Recognizing obesity as a key comorbidity is essential to develop targeted strategies for prevention of COVID-19 complications in children.
Keywords: COVID-19; adolescent; child; intensive care units; obesity; post-acute COVID-19 syndrome.