tetano
Editor, Senior Moderator
Pediatr Neurol
. 2023 Jun 1;145:148-153.
doi: 10.1016/j.pediatrneurol.2023.05.018. Online ahead of print. Coronavirus Disease 2019-Associated Neurological Manifestations in Children: A Large Single-Center Experience With Rare Cases
Olgay Bildik[SUP] 1 [/SUP], Nihal Olgac Dundar[SUP] 2 [/SUP], Gunce Basarir[SUP] 1 [/SUP], Atilla Ersen[SUP] 1 [/SUP], Sema Bozkaya Yilmaz[SUP] 1 [/SUP], Fatma Kusgöz[SUP] 1 [/SUP], Aslihan Sahin[SUP] 3 [/SUP], Pinar Gencpinar[SUP] 4 [/SUP], Dilek Yılmaz Ciftdogan[SUP] 5 [/SUP]
Affiliations
Background: We aimed to analyze pediatric patients with coronavirus disease 2019 (COVID-19) with a diverse spectrum of neurological manifestations in a single center since neurological involvement in children is still poorly understood.
Methods: We performed a retrospective study on 912 children aged between zero and 18 years who had a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test result and symptoms of COVID-19 from March 2020 to March 2021 in a single center.
Results: Among 912 patients, 37.5% (n = 342) had neurological symptoms and 62.5% (n = 570) had no neurological symptoms. The mean age of patients with neurological symptoms was significantly higher (14.2 ± 3.7 vs 9.9 ± 5.7; P < 0.001). Three hundred and twenty-two patients had nonspecific symptoms (ageusia, anosmia, parosmia, headache, vertigo, myalgia), whereas 20 patients had specific involvement (seizures/febrile infection-related epilepsy syndrome, cranial nerve palsy, Guillain-Barré syndrome and variants, acute disseminated encephalomyelitis, central nervous system vasculitis). The mean age of the patients with nonspecific neurological symptoms was significantly higher (14.6 ± 3.1 vs 7.7 ± 5.7; P < 0.001).
Conclusion: This study presents a large number of patients with a diverse spectrum of neurological manifestations. The rare neurological manifestations reported in our study will contribute to better understanding the neurological involvement of SARS-CoV-2 in children. The study also points out the differences of SARS-CoV-2-related neurological manifestations between patients at different ages. Physicians should be alert about recognizing the early neurological manifestations of the SARS-CoV-2 in children.
Keywords: COVID-19; Children; Neurological; Pediatric; SARS-CoV-2.
. 2023 Jun 1;145:148-153.
doi: 10.1016/j.pediatrneurol.2023.05.018. Online ahead of print. Coronavirus Disease 2019-Associated Neurological Manifestations in Children: A Large Single-Center Experience With Rare Cases
Olgay Bildik[SUP] 1 [/SUP], Nihal Olgac Dundar[SUP] 2 [/SUP], Gunce Basarir[SUP] 1 [/SUP], Atilla Ersen[SUP] 1 [/SUP], Sema Bozkaya Yilmaz[SUP] 1 [/SUP], Fatma Kusgöz[SUP] 1 [/SUP], Aslihan Sahin[SUP] 3 [/SUP], Pinar Gencpinar[SUP] 4 [/SUP], Dilek Yılmaz Ciftdogan[SUP] 5 [/SUP]
Affiliations
- PMID: 37369146
- DOI: 10.1016/j.pediatrneurol.2023.05.018
Background: We aimed to analyze pediatric patients with coronavirus disease 2019 (COVID-19) with a diverse spectrum of neurological manifestations in a single center since neurological involvement in children is still poorly understood.
Methods: We performed a retrospective study on 912 children aged between zero and 18 years who had a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test result and symptoms of COVID-19 from March 2020 to March 2021 in a single center.
Results: Among 912 patients, 37.5% (n = 342) had neurological symptoms and 62.5% (n = 570) had no neurological symptoms. The mean age of patients with neurological symptoms was significantly higher (14.2 ± 3.7 vs 9.9 ± 5.7; P < 0.001). Three hundred and twenty-two patients had nonspecific symptoms (ageusia, anosmia, parosmia, headache, vertigo, myalgia), whereas 20 patients had specific involvement (seizures/febrile infection-related epilepsy syndrome, cranial nerve palsy, Guillain-Barré syndrome and variants, acute disseminated encephalomyelitis, central nervous system vasculitis). The mean age of the patients with nonspecific neurological symptoms was significantly higher (14.6 ± 3.1 vs 7.7 ± 5.7; P < 0.001).
Conclusion: This study presents a large number of patients with a diverse spectrum of neurological manifestations. The rare neurological manifestations reported in our study will contribute to better understanding the neurological involvement of SARS-CoV-2 in children. The study also points out the differences of SARS-CoV-2-related neurological manifestations between patients at different ages. Physicians should be alert about recognizing the early neurological manifestations of the SARS-CoV-2 in children.
Keywords: COVID-19; Children; Neurological; Pediatric; SARS-CoV-2.