tetano
Editor, Senior Moderator
Pediatr Int
. 2026 Jan-Dec;68(1):e70420.
doi: 10.1111/ped.70420.
Ascertaining the Kawasaki Disease-Coronavirus Disease 2019 Linkage in a Japanese Administrative Claims Database
Tomoki Mizuno[SUP] 1 2 [/SUP], Jun Suzuki[SUP] 1 2 3 4 [/SUP], Shota Takahashi[SUP] 2 [/SUP], Haruka Imai[SUP] 1 2 [/SUP], Hideya Itagaki[SUP] 4 [/SUP], Tomohiro Akaba[SUP] 5 [/SUP], Makiko Yoshida[SUP] 2 3 4 6 [/SUP], Shiro Endo[SUP] 1 2 3 4 6 [/SUP]
Affiliations
Background: Despite the potential association between Kawasaki Disease (KD) and coronavirus disease 2019 (COVID-19), real-world clinical associations remain unclear. We aimed to investigate the association between KD and COVID-19 using a Japanese claims database.
Methods: Using a Japanese claims database, we identified patients diagnosed with COVID-19 between January 1, 2020, and December 31, 2022 and conducted the following two analyses: a nested case-control study wherein each KD case was matched 1:4 to controls (without KD), and conditional logistic regression analyses were used to calculate odds ratios (ORs) for COVID-19 exposure in the previous 1-30, 31-60, and 61-90 days. In the self-controlled case-series (SCCS) analysis, the observation comprised the 120 days before and after COVID-19 diagnosis (Day 0). We calculated the incidence rate ratio (IRR) of three risk periods (Days 1-30, 31-60, 61-90) after Day 0 compared with the control periods.
Results: Nested case-control analysis matched 134 cases with 536 controls. COVID-19 exposure was identified in 26.1% (35/134) of cases and 7.3% (39/536) of controls during the previous 1-30 days (adjusted OR 7.8, 95% CI 3.2-19), and in 18.7% (25/134) and 8.8% (47/536) during the previous 31-60 days (adjusted OR 3.6, 95% CI 2.0-6.5). SCCS analysis included 124 patients, revealing elevated IRRs on Days 1-30 (95% CI: 11 [6.0-20]), and 31-60 (6.9 [3.6-13]) after COVID-19 diagnosis.
Conclusion: The present study found that COVID-19 was associated with the development of KD.
Keywords: COVID‐19; SARS‐CoV‐2; multisystem inflammatory syndrome in children; severe acute respiratory syndrome coronavirus 2.
. 2026 Jan-Dec;68(1):e70420.
doi: 10.1111/ped.70420.
Ascertaining the Kawasaki Disease-Coronavirus Disease 2019 Linkage in a Japanese Administrative Claims Database
Tomoki Mizuno[SUP] 1 2 [/SUP], Jun Suzuki[SUP] 1 2 3 4 [/SUP], Shota Takahashi[SUP] 2 [/SUP], Haruka Imai[SUP] 1 2 [/SUP], Hideya Itagaki[SUP] 4 [/SUP], Tomohiro Akaba[SUP] 5 [/SUP], Makiko Yoshida[SUP] 2 3 4 6 [/SUP], Shiro Endo[SUP] 1 2 3 4 6 [/SUP]
Affiliations
- PMID: 42047448
- PMCID: PMC13123303
- DOI: 10.1111/ped.70420
Background: Despite the potential association between Kawasaki Disease (KD) and coronavirus disease 2019 (COVID-19), real-world clinical associations remain unclear. We aimed to investigate the association between KD and COVID-19 using a Japanese claims database.
Methods: Using a Japanese claims database, we identified patients diagnosed with COVID-19 between January 1, 2020, and December 31, 2022 and conducted the following two analyses: a nested case-control study wherein each KD case was matched 1:4 to controls (without KD), and conditional logistic regression analyses were used to calculate odds ratios (ORs) for COVID-19 exposure in the previous 1-30, 31-60, and 61-90 days. In the self-controlled case-series (SCCS) analysis, the observation comprised the 120 days before and after COVID-19 diagnosis (Day 0). We calculated the incidence rate ratio (IRR) of three risk periods (Days 1-30, 31-60, 61-90) after Day 0 compared with the control periods.
Results: Nested case-control analysis matched 134 cases with 536 controls. COVID-19 exposure was identified in 26.1% (35/134) of cases and 7.3% (39/536) of controls during the previous 1-30 days (adjusted OR 7.8, 95% CI 3.2-19), and in 18.7% (25/134) and 8.8% (47/536) during the previous 31-60 days (adjusted OR 3.6, 95% CI 2.0-6.5). SCCS analysis included 124 patients, revealing elevated IRRs on Days 1-30 (95% CI: 11 [6.0-20]), and 31-60 (6.9 [3.6-13]) after COVID-19 diagnosis.
Conclusion: The present study found that COVID-19 was associated with the development of KD.
Keywords: COVID‐19; SARS‐CoV‐2; multisystem inflammatory syndrome in children; severe acute respiratory syndrome coronavirus 2.