tetano
Editor, Senior Moderator
Pediatr Infect Dis J
. 2021 Aug 10.
doi: 10.1097/INF.0000000000003294. Online ahead of print.
Racial and Ethnic Disparities in Multisystem Inflammatory Syndrome in Children in the United States, March 2020 to February 2021
Bryan Stierman[SUP] 1 [/SUP], Joseph Y Abrams, Shana E Godfred-Cato, Matthew E Oster, Lu Meng, Luke Yip, Pragna Patel, Neha Balachandran, Emily Prezzato, Timmy Pierce, Katherine K Hsu, Meagan Burns, Xandy Peterson Pompa, Priscilla Lauro, Amanda Hartley, Cassandra Jones, Stephanie Gretsch, Heather Reid, Sarah Lim, Angela P Campbell, Ermias D Belay
Affiliations
Abstract
Background: The incidence of multisystem inflammatory syndrome in children (MIS-C) varies by race and ethnicity. This study assessed whether disparities in MIS-C in the United States by race and ethnicity exceed known disparities in coronavirus disease 2019 (COVID-19) incidence.
Methods: We compared the distribution of race and ethnicity among patients with MIS-C (aged <21 years, termed children) with onset March 2020 to February 2021 to that of children with COVID-19 and in the general population. Analysis was restricted to 369 counties with high completeness of race and ethnicity reporting for MIS-C and COVID-19. For each racial and ethnic group, observed numbers of patients with MIS-C were compared with expected numbers (observed/expected ratio) in children with COVID-19 and in the general population within these counties.
Results: Compared with children in the general population, MIS-C was more frequent among Hispanic (139% of expected) and non-Hispanic Black children (183%) and less frequent among non-Hispanic White (64%) and non-Hispanic Asian children (48%). Compared with children with COVID-19, MIS-C was more frequent in non-Hispanic Black children (207% of expected) and less frequent in non-Hispanic White children (68%); however, frequency was not different among Hispanic (102%) and non-Hispanic Asian (74%) children.
Conclusions: Disparities in MIS-C by race and ethnicity exist, even after controlling for COVID-19 disparities and geographic variations. The high proportion of MIS-C among Hispanic children and low proportion among non-Hispanic Asian children align with COVID-19 rates, while the high proportion among non-Hispanic Black children and low proportion among non-Hispanic White children are not explainable by COVID-19 rates.
. 2021 Aug 10.
doi: 10.1097/INF.0000000000003294. Online ahead of print.
Racial and Ethnic Disparities in Multisystem Inflammatory Syndrome in Children in the United States, March 2020 to February 2021
Bryan Stierman[SUP] 1 [/SUP], Joseph Y Abrams, Shana E Godfred-Cato, Matthew E Oster, Lu Meng, Luke Yip, Pragna Patel, Neha Balachandran, Emily Prezzato, Timmy Pierce, Katherine K Hsu, Meagan Burns, Xandy Peterson Pompa, Priscilla Lauro, Amanda Hartley, Cassandra Jones, Stephanie Gretsch, Heather Reid, Sarah Lim, Angela P Campbell, Ermias D Belay
Affiliations
- PMID: 34382615
- DOI: 10.1097/INF.0000000000003294
Abstract
Background: The incidence of multisystem inflammatory syndrome in children (MIS-C) varies by race and ethnicity. This study assessed whether disparities in MIS-C in the United States by race and ethnicity exceed known disparities in coronavirus disease 2019 (COVID-19) incidence.
Methods: We compared the distribution of race and ethnicity among patients with MIS-C (aged <21 years, termed children) with onset March 2020 to February 2021 to that of children with COVID-19 and in the general population. Analysis was restricted to 369 counties with high completeness of race and ethnicity reporting for MIS-C and COVID-19. For each racial and ethnic group, observed numbers of patients with MIS-C were compared with expected numbers (observed/expected ratio) in children with COVID-19 and in the general population within these counties.
Results: Compared with children in the general population, MIS-C was more frequent among Hispanic (139% of expected) and non-Hispanic Black children (183%) and less frequent among non-Hispanic White (64%) and non-Hispanic Asian children (48%). Compared with children with COVID-19, MIS-C was more frequent in non-Hispanic Black children (207% of expected) and less frequent in non-Hispanic White children (68%); however, frequency was not different among Hispanic (102%) and non-Hispanic Asian (74%) children.
Conclusions: Disparities in MIS-C by race and ethnicity exist, even after controlling for COVID-19 disparities and geographic variations. The high proportion of MIS-C among Hispanic children and low proportion among non-Hispanic Asian children align with COVID-19 rates, while the high proportion among non-Hispanic Black children and low proportion among non-Hispanic White children are not explainable by COVID-19 rates.